Vaccines 2014, 2(3), 549-562; https://doi.org/10.3390/vaccines2030549
Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen Modification
Department of Chemistry, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, China
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Received: 25 March 2014 / Revised: 30 May 2014 / Accepted: 4 June 2014 / Published: 15 July 2014
(This article belongs to the Special Issue Peptide Vaccine)
Abstract
Synthetic tumor vaccines have been proven to be promising for cancer immunotherapy. However, the limitation of the specificity and efficiency of the synthetic tumor vaccines need further improvements. To overcome these difficulties, additional tumor-associated targets need to be identified, and optimized structural designs of vaccines need to be elaborated. In this review, we summarized the main strategies pursued in the design of synthetic tumor vaccines, such as multi-component, multivalency, antigen modification and other possible ways to improve the efficiency of synthetic tumor vaccines. View Full-TextKeywords:
tumor; vaccine; multi-component; multivalency; nano-size
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Huang, Z.-H.; Sun, Z.-Y.; Gao, Y.; Chen, P.-G.; Liu, Y.-F.; Chen, Y.-X.; Li, Y.-M. Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen Modification. Vaccines 2014, 2, 549-562.
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