Correction: Hernández-Pedro et al. Impact of Tyrosine Kinase Inhibitors on the Immune Response to SARS-CoV-2 Vaccination in Patients with Thoracic Malignancies. Vaccines 2023, 11, 1612

The authors would like to make the following corrections to this published paper [1].

The title of the paper should be updated from “Impact of Tyrosine Kinase Inhibitors on the Immune Response to SARS-CoV-2 Vaccination in Patients with Non-Small Cell Lung Cancer” to “Impact of Tyrosine Kinase Inhibitors on the Immune Response to SARS-CoV-2 Vaccination in Patients with Thoracic Malignancies”, to describe all included patients.

The authors would like to clarify that all individuals receiving the CanSino vaccine at the time of this study received only one dose. Therefore, to avoid confusion, in the second paragraph of Section 2.1. “Study Design and Participants”, the sentence “…or inactivated virus vaccines like Sinovac-CoronaVac in one or two doses according to the pre-established scheme” is changed to “…or inactivated virus vaccines like Sinovac-CoronaVac in one (CanSino) or two doses (all others) according to the pre-established scheme.” In the fifth paragraph of Section 2.1. “Study Design and Participants”, the second sentence “Blood samples were collected 30 days after the second dose of the COVID-19 vaccine to…” is changed to “Blood samples were collected 30 days after scheme completion of the COVID-19 vaccine to…”.

As currently published, some proportions were not accurately located within each section in Table 2. Moreover, additional changes were made to subtitles to improve their clarity. The title of Table 2 has been updated to “Clinical features of thoracic malignancy patients stratified by SARS CoV-2 antigen load and titles” to describe all included patients. The correct Table 2 appears below.

Table 2. Clinical features of thoracic malignancy patients stratified by SARS CoV-2 antigen load and titles.

Clinical Characteristics	SARS-COV-2 Antigen (>20)	SARS-COV-2 Antigen (<20)	p-Value	SARS-COV-2 Titles (−)	SARS-COV-2 Titles (+)	p-Value
N = 92	% (n)	% (n)		% (n)	% (n)
Sex
Male: 39	46.2 (18)	53.8 (21)		46.2 (18)	53.8 (21)
Female: 53	45.3 (24)	54.7 (29)	0.934	50.9 (27)	49.1 (26)	0.650
Age
<59: 41	34.1 (14)	65.9 (27)		39.0 (16)	61.0 (25)
≥59: 51	54.9 (28)	45.1 (23)	0.047	56.9 (29)	43.1 (22)	0.089
Smoking status
No: 67	41.8 (28)	58.2 (39)		46.3 (31)	53.7 (36)
Yes: 25	56.0 (14)	44.0 (11)	0.224	56.0 (14)	44.0 (11)	0.406
Woodsmoke exposure
No: 72	48.6 (35)	51.4 (37)		50.0 (36)	50.0 (36)
Yes: 20	35.0 (7)	65.0 (13)	0.280	45.0 (9)	55.0 (11)	0.692
Asbestos exposure
No: 82	47.6 (39)	52.4 (43)		50.0 (41)	50.0 (41)
Yes: 10	30.0 (3)	70.0 (7)	0.336 *	40.0 (4)	60.0 (6)	0.740 *
ECOG PS
0–1: 86	47.7 (41)	52.3 (45)		51.2 (44)	48.8 (42)
>2: 6	16.7 (1)	83.3 (5)	0.214 *	16.7 (1)	83.3 (5)	0.204 *
Clinical stage
I–III: 10	60.0 (6)	40.0 (4)		60.0 (6)	40.0 (4)
IV: 82	43.9 (36)	56.1 (46)	0.503 *	47.6 (39)	52.4 (43)	0.518 *
Histology
Adenocarcinoma: 79	44.3 (35)	55.7 (44)		48.1 (38)	51.9 (41)
Squamous: 4	75.0 (3)	25.0 (1)		75.0 (3)	25.0 (1)
Mesothelioma: 5	20.0 (1)	80.0 (4)		20.0 (1)	80.0 (4)
Others: 4	75.0 (3)	25.0 (1)	0.245	75.0 (3)	25.0 (1)	0.276
Histological grade
Low: 15	46.7 (7)	53.3 (8)		53.3 (8)	46.7 (7)
Intermediate: 27	51.9 (14)	48.1 (13)		51.9 (14)	48.1 (13)
High: 23	34.8 (8)	65.2 (15)		34.8 (8)	65.2 (15)
n/a: 14	42.9 (6)	57.1 (8)	0.679	57.1 (8)	42.9 (6)	0.492
Metastases
CNS: 23	47.8 (11)	52.2 (12)	0.809	52.2 (12)	47.8 (11)	0.718
Liver: 7	42.9 (3)	57.1 (4)	1.00 *	42.9 (3)	57.1 (4)	1.00 *
Lung: 60	48.3 (29)	51.7 (31)	0.480	51.7 (31)	48.3 (29)	0.469
Ganglia: 8	62.5 (5)	37.5 (3)	0.317 *	62.5 (5)	37.5 (3)	0.481 *
Bone: 28	35.7 (10)	64.3 (18)	0.206	42.9 (12)	57.1 (16)	0.442
Pulmonary effusion: 31	51.6 (16)	48.4 (15)	0.413	58.1 (18)	41.9 (13)	0.211
EGFR
Wild type: 54	44.4 (24)	55.6 (30)		46.3 (25)	53.7 (29)
Mutant: 38	47.4 (18)	52.6 (20)	0.782	52.6 (20)	47.4 (18)	0.549
EGFR subtype
Exon 19 del: 26	42.3 (11)	57.7 (15)	0.686	46.2 (12)	53.8 (14)	0.740
Exon 21 L858R: 12	50.0 (6)	50.0 (6)	0.746	58.3 (7)	41.7 (5)	0.547 *
Exon 20 T790M: 1	100 (1)	0.0 (0)	0.457 *	100 (1)	0.0 (0)	0.489 *
ALK
Wild type: 68	51.5 (35)	48.5 (33)		54.4 (37)	45.6 (31)
Mutant: 24	29.2 (7)	70.8 (17)	0.059	33.3 (8)	66.7 (16)	0.076
TKI treatment
No: 20	55.0 (11)	45.0 (9)		55.0 (11)	45.0 (9)
Yes: 55	40.0 (22)	60.0 (33)	0.247	45.5 (25)	54.5 (30)	0.464
QT treatment
No: 61	41.0 (25)	59.0 (36)		45.9 (28)	54.1 (33)
Yes: 31	54.8 (17)	45.2 (14)	0.207	54.8 (17)	45.2 (14)	0.418
Vaccine
BNT162b2: 31	48.4 (15)	51.6 (16)		48.4 (15)	51.6 (16)
AZD1222: 37	45.9 (17)	54.1 (20)		48.6 (18)	51.4 (19)
Sputnik: 10	50.0 (5)	50.0 (5)		50.0 (5)	50.0 (5)
Sinovac: 13	38.5 (5)	61.5 (8)		46.2 (6)	53.8 (7)
Cansino: 1	0.0 (0)	100 (1)	0.864	100 (1)	0 (0)	0.895
COVID-19
No: 82	47.6 (39)	52.4 (43)		51.2 (42)	48.8 (40)
Yes: 10	30.0 (3)	70.0 (7)	0.336 *	30.0 (3)	70.0 (7)	0.317 *

* Fisher’s exact test. All other comparisons were performed using the chi-square test.

Table 2. Clinical features of thoracic malignancy patients stratified by SARS CoV-2 antigen load and titles.

Clinical Characteristics	SARS-COV-2 Antigen (>20)	SARS-COV-2 Antigen (<20)	p-Value	SARS-COV-2 Titles (−)	SARS-COV-2 Titles (+)	p-Value
N = 92	% (n)	% (n)		% (n)	% (n)
Sex
Male: 39	46.2 (18)	53.8 (21)		46.2 (18)	53.8 (21)
Female: 53	45.3 (24)	54.7 (29)	0.934	50.9 (27)	49.1 (26)	0.650
Age
<59: 41	34.1 (14)	65.9 (27)		39.0 (16)	61.0 (25)
≥59: 51	54.9 (28)	45.1 (23)	0.047	56.9 (29)	43.1 (22)	0.089
Smoking status
No: 67	41.8 (28)	58.2 (39)		46.3 (31)	53.7 (36)
Yes: 25	56.0 (14)	44.0 (11)	0.224	56.0 (14)	44.0 (11)	0.406
Woodsmoke exposure
No: 72	48.6 (35)	51.4 (37)		50.0 (36)	50.0 (36)
Yes: 20	35.0 (7)	65.0 (13)	0.280	45.0 (9)	55.0 (11)	0.692
Asbestos exposure
No: 82	47.6 (39)	52.4 (43)		50.0 (41)	50.0 (41)
Yes: 10	30.0 (3)	70.0 (7)	0.336 *	40.0 (4)	60.0 (6)	0.740 *
ECOG PS
0–1: 86	47.7 (41)	52.3 (45)		51.2 (44)	48.8 (42)
>2: 6	16.7 (1)	83.3 (5)	0.214 *	16.7 (1)	83.3 (5)	0.204 *
Clinical stage
I–III: 10	60.0 (6)	40.0 (4)		60.0 (6)	40.0 (4)
IV: 82	43.9 (36)	56.1 (46)	0.503 *	47.6 (39)	52.4 (43)	0.518 *
Histology
Adenocarcinoma: 79	44.3 (35)	55.7 (44)		48.1 (38)	51.9 (41)
Squamous: 4	75.0 (3)	25.0 (1)		75.0 (3)	25.0 (1)
Mesothelioma: 5	20.0 (1)	80.0 (4)		20.0 (1)	80.0 (4)
Others: 4	75.0 (3)	25.0 (1)	0.245	75.0 (3)	25.0 (1)	0.276
Histological grade
Low: 15	46.7 (7)	53.3 (8)		53.3 (8)	46.7 (7)
Intermediate: 27	51.9 (14)	48.1 (13)		51.9 (14)	48.1 (13)
High: 23	34.8 (8)	65.2 (15)		34.8 (8)	65.2 (15)
n/a: 14	42.9 (6)	57.1 (8)	0.679	57.1 (8)	42.9 (6)	0.492
Metastases
CNS: 23	47.8 (11)	52.2 (12)	0.809	52.2 (12)	47.8 (11)	0.718
Liver: 7	42.9 (3)	57.1 (4)	1.00 *	42.9 (3)	57.1 (4)	1.00 *
Lung: 60	48.3 (29)	51.7 (31)	0.480	51.7 (31)	48.3 (29)	0.469
Ganglia: 8	62.5 (5)	37.5 (3)	0.317 *	62.5 (5)	37.5 (3)	0.481 *
Bone: 28	35.7 (10)	64.3 (18)	0.206	42.9 (12)	57.1 (16)	0.442
Pulmonary effusion: 31	51.6 (16)	48.4 (15)	0.413	58.1 (18)	41.9 (13)	0.211
EGFR
Wild type: 54	44.4 (24)	55.6 (30)		46.3 (25)	53.7 (29)
Mutant: 38	47.4 (18)	52.6 (20)	0.782	52.6 (20)	47.4 (18)	0.549
EGFR subtype
Exon 19 del: 26	42.3 (11)	57.7 (15)	0.686	46.2 (12)	53.8 (14)	0.740
Exon 21 L858R: 12	50.0 (6)	50.0 (6)	0.746	58.3 (7)	41.7 (5)	0.547 *
Exon 20 T790M: 1	100 (1)	0.0 (0)	0.457 *	100 (1)	0.0 (0)	0.489 *
ALK
Wild type: 68	51.5 (35)	48.5 (33)		54.4 (37)	45.6 (31)
Mutant: 24	29.2 (7)	70.8 (17)	0.059	33.3 (8)	66.7 (16)	0.076
TKI treatment
No: 20	55.0 (11)	45.0 (9)		55.0 (11)	45.0 (9)
Yes: 55	40.0 (22)	60.0 (33)	0.247	45.5 (25)	54.5 (30)	0.464
QT treatment
No: 61	41.0 (25)	59.0 (36)		45.9 (28)	54.1 (33)
Yes: 31	54.8 (17)	45.2 (14)	0.207	54.8 (17)	45.2 (14)	0.418
Vaccine
BNT162b2: 31	48.4 (15)	51.6 (16)		48.4 (15)	51.6 (16)
AZD1222: 37	45.9 (17)	54.1 (20)		48.6 (18)	51.4 (19)
Sputnik: 10	50.0 (5)	50.0 (5)		50.0 (5)	50.0 (5)
Sinovac: 13	38.5 (5)	61.5 (8)		46.2 (6)	53.8 (7)
Cansino: 1	0.0 (0)	100 (1)	0.864	100 (1)	0 (0)	0.895
COVID-19
No: 82	47.6 (39)	52.4 (43)		51.2 (42)	48.8 (40)
Yes: 10	30.0 (3)	70.0 (7)	0.336 *	30.0 (3)	70.0 (7)	0.317 *

* Fisher’s exact test. All other comparisons were performed using the chi-square test.

In Section 3.1 “Clinical Characteristics”, some proportions did not match between the text and Tables 1 and 2. Corrections have been made here. Specifically, the fourth and fifth sentences were updated to “In the lung cancer cohort, 89.2% (n = 82) of patients had IV-stage disease, and only 10.8% (n = 10) were early-stage. Adenocarcinoma was the most common type of cancer in the overall sample, 85.9% (n = 79), while mesothelioma, 5.4% (n = 5), squamous cell carcinoma, 4.3% (n = 4), and other, 4.3% (n = 4), were found in a smaller proportion of cases (Table 2)”. The citation to Table 2 at the end of this paragraph was removed and added in the fifth sentence.

The paragraph in Section 3.2 “SARS-CoV-2 Vaccines Distribution” should be changed to the following after a detailed review of data:

“In the healthy cohort, 33.3% (n = 9) of subjects received Oxford/AstraZeneca (AZD1222), 33.3% (n = 9) Pfizer-BioNTech (BNT162b2), 18.5% (n = 5) Johnson & Johnson’s Janssen, 11.1% (n = 3) Sputnik V, and 3.7% (n = 1) Sinovac. In the meantime, NSCLC patients received AZD1222 in 40.2% (n = 37), BNT162b2 in 33.7% (n = 31), Sinovac in 14.1% (n = 13), Sputnik V in 10.9% (n = 10), and CanSino in only 1.1% (n = 1) of cases (Table 1).”

The title of Table 3, “SARS-CoV-2 vaccine-related adverse effects in NSCLC patients according to Common Terminology Criteria for Adverse Events (CTCAE v5.0) scale”, must be modified to the following version according to the Materials and Methods: “SARS-CoV-2 vaccine-related adverse effects in NSCLC patients according to the Mexican Official Standard for epidemiological surveillance [12]”, as this was the scale used for measuring vaccine-related adverse effects, and to maintain methodological precision and consistency. Additionally, ‘SARS-CoV-2 Neutralizing Antibodies’ was added as a column header to accurately describe the detection methodology underlying these measurements. The newly added ref. [12] and correct Table 3 appear below.

12.

Tapia-Conyer, R.; Kuri-Morales, P.; González-Urbán, L.; Sarti, E. Evaluation and Reform of Mexican National Epidemiological Surveillance System. Am. J. Public Health 2001, 91, 1758–1760. https://doi.org/10.2105/ajph.91.11.1758.

Table 3. SARS-CoV-2 vaccine-related adverse effects in NSCLC patients according to the Mexican Official Standard for epidemiological surveillance [12].

Clinical Characteristics	Neutralization Antibodies for SARS-COV-2 Virus (Cut-Off > 20)	Neutralization Antibodies for SARS-COV-2 Virus (Cut-Off < 20)	p-Value	SARS-COV-2 Antibodies Titles (−)	SARS-COV-2 Antibodies Titles (+)	p-Value
N = 92	% (n)	% (n)		% (n)	% (n)
Sex
Male: 39	46.2 (18)	53.8 (21)		46.2 (18)	53.8 (21)
Female: 53	45.3 (24)	54.7 (29)	0.934	50.9 (27)	49.1 (26)	0.678
Age
<59: 41	34.1 (14)	65.9 (27)		39.0 (16)	61.0 (25)
≥59: 51	54.9 (28)	45.1 (23)	0.047	56.9 (29)	43.1 (22)	0.098
Smoking status
No: 67	41.8 (28)	58.2 (39)		46.3 (31)	53.7 (36)
Yes: 25	56.0 (14)	44.0 (11)	0.224	56 (14)	44.0 (11)	0.485
Woodsmoke exposure
No: 72	48.6 (35)	51.4 (37)		50.0 (36)	50.0 (36)
Yes: 20	35.0 (7)	65.0 (13)	0.280	45.0 (9)	55.0 (11)	0.802
Asbestos exposure
No: 82	47.6 (39)	52.4 (43)		50 (41)	50 (41)
Yes: 10	30.0 (3)	70.0 (7)	0.293	40 (4)	60 (6)	0.740
ECOG PS
0–1: 86	47.7 (41)	52.3 (45)		51.2 (44)	48.8 (42)
>2: 6	16.7 (1)	83.3 (5)	0.214	16.7 (1)	83.3 (5)	0.204
Clinical stage
I–III: 10	60.0 (6)	40.0 (4)		60.0 (6)	40.0 (4)
IV: 82	43.9 (36)	56.1 (46)	0.503	47.6 (39)	52.4 (43)	0.518
Histology
Adenocarcinoma: 79	44.3 (35)	55.7 (44)		48.1 (38)	51.9 (41)
Squamous: 4	75.0 (3)	25.0 (1)		75.0 (3)	25.0 (1)
Mesothelioma: 5	20.0 (1)	80.0 (4)		20.0 (1)	80.0 (4)
Others: 4	75.0 (3)	25.0 (1)	0.245	75.0 (3)	25.0 (1)	0.276
Histological grade
Low: 15	46.7 (7)	53.3 (8)		53.3 (8)	46.7 (7)
Intermediate: 27	51.9 (14)	48.1 (13)		51.9 (14)	48.1 (13)
High: 23	34.8 (8)	65.2 (15)		34.8 (8)	65.2 (15)
n/a: 14	42.9 (6)	57.1 (8)	0.679	57.1 (8)	42.9 (6)	0.492
Metastases *
CNS: 23	47.8 (11)	52.2 (12)	0.809	52.2 (12)	47.8 (11)	0.811
Liver: 7	42.9 (3)	57.1 (4)	0.877	42.9 (3)	57.1 (4)	1.00
Lung: 60	48.3 (29)	51.7 (31)	0.480	51.7 (31)	48.3 (29)	0.517
Ganglia: 8	62.5 (5)	37.5 (3)	0.317	62.5 (5)	37.5 (3)	0.481
Bone: 28	35.7 (10)	64.3 (18)	0.206	42.9 (12)	57.1 (16)	0.501
Pulmonary effusion: 31	51.6 (16)	48.4 (15)	0.413	58.1 (18)	41.9 (13)	0.271
EGFR
Wild type: 54	44.4 (24)	55.6 (30)		46.3 (25)	53.7 (29)
Mutant: 38	47.4 (18)	52.6 (20)	0.782	52.6 (20)	47.4 (18)	0.672
EGFR subtype
Exon 19 del: 26	42.3 (11)	57.7 (15)	0.686	46.2 (12)	53.8 (14)	0.819
Exon 21 L858R: 12	50.0 (6)	50.0 (6)	0.746	58.3 (7)	41.7 (5)	0.547
Exon 20 T790M: 1	100 (1)	0.0 (0)	0.273	100 (1)	0.0 (0)	0.489
ALK
Wild type: 68	51.5 (35)	48.5 (33)		54.4 (37)	45.6 (31)
Mutant: 24	29.2 (7)	70.8 (17)	0.059	33.3 (8)	66.7 (16)	0.098
TKI treatment
No: 20	55.0 (11)	45.0 (9)		55.0 (11)	45.0 (9)
Yes: 55	40.0 (22)	60.0 (33)	0.247	45.5 (25)	54.5 (30)	0.602
QT treatment
No: 61	41.0 (25)	59.0 (36)		45.9 (28)	54.1 (33)
Yes: 31	54.8 (17)	45.2 (14)	0.207	54.8 (17)	45.2 (14)	0.509
Vaccine
BNT162b2: 31	48.4 (15)	51.6 (16)		48.4 (15)	51.6 (16)
AZD1222: 36	45.9 (17)	54.1 (20)		48.6 (18)	51.4 (19)
Sputnik: 10	50.0 (5)	50.0 (5)		50.0 (5)	50.0 (5)
Sinovac: 13	38.5 (5)	61.5 (8)		46.2 (6)	53.8 (7)
Cansino: 1	0.0 (0)	100 (1)	0.864	100 (1)	0 (0)	0.895
COVID-19
No: 82	47.6 (39)	52.4 (43)		51.2 (42)	48.8 (40)
Yes: 10	30.0 (3)	70.0 (7)	0.293	30.0 (3)	70.0 (7)	0.317

* Each patient can have more than one metastatic site, resulting in a total of 157 in all 92 patients.

Table 3. SARS-CoV-2 vaccine-related adverse effects in NSCLC patients according to the Mexican Official Standard for epidemiological surveillance [12].

Clinical Characteristics	Neutralization Antibodies for SARS-COV-2 Virus (Cut-Off > 20)	Neutralization Antibodies for SARS-COV-2 Virus (Cut-Off < 20)	p-Value	SARS-COV-2 Antibodies Titles (−)	SARS-COV-2 Antibodies Titles (+)	p-Value
N = 92	% (n)	% (n)		% (n)	% (n)
Sex
Male: 39	46.2 (18)	53.8 (21)		46.2 (18)	53.8 (21)
Female: 53	45.3 (24)	54.7 (29)	0.934	50.9 (27)	49.1 (26)	0.678
Age
<59: 41	34.1 (14)	65.9 (27)		39.0 (16)	61.0 (25)
≥59: 51	54.9 (28)	45.1 (23)	0.047	56.9 (29)	43.1 (22)	0.098
Smoking status
No: 67	41.8 (28)	58.2 (39)		46.3 (31)	53.7 (36)
Yes: 25	56.0 (14)	44.0 (11)	0.224	56 (14)	44.0 (11)	0.485
Woodsmoke exposure
No: 72	48.6 (35)	51.4 (37)		50.0 (36)	50.0 (36)
Yes: 20	35.0 (7)	65.0 (13)	0.280	45.0 (9)	55.0 (11)	0.802
Asbestos exposure
No: 82	47.6 (39)	52.4 (43)		50 (41)	50 (41)
Yes: 10	30.0 (3)	70.0 (7)	0.293	40 (4)	60 (6)	0.740
ECOG PS
0–1: 86	47.7 (41)	52.3 (45)		51.2 (44)	48.8 (42)
>2: 6	16.7 (1)	83.3 (5)	0.214	16.7 (1)	83.3 (5)	0.204
Clinical stage
I–III: 10	60.0 (6)	40.0 (4)		60.0 (6)	40.0 (4)
IV: 82	43.9 (36)	56.1 (46)	0.503	47.6 (39)	52.4 (43)	0.518
Histology
Adenocarcinoma: 79	44.3 (35)	55.7 (44)		48.1 (38)	51.9 (41)
Squamous: 4	75.0 (3)	25.0 (1)		75.0 (3)	25.0 (1)
Mesothelioma: 5	20.0 (1)	80.0 (4)		20.0 (1)	80.0 (4)
Others: 4	75.0 (3)	25.0 (1)	0.245	75.0 (3)	25.0 (1)	0.276
Histological grade
Low: 15	46.7 (7)	53.3 (8)		53.3 (8)	46.7 (7)
Intermediate: 27	51.9 (14)	48.1 (13)		51.9 (14)	48.1 (13)
High: 23	34.8 (8)	65.2 (15)		34.8 (8)	65.2 (15)
n/a: 14	42.9 (6)	57.1 (8)	0.679	57.1 (8)	42.9 (6)	0.492
Metastases *
CNS: 23	47.8 (11)	52.2 (12)	0.809	52.2 (12)	47.8 (11)	0.811
Liver: 7	42.9 (3)	57.1 (4)	0.877	42.9 (3)	57.1 (4)	1.00
Lung: 60	48.3 (29)	51.7 (31)	0.480	51.7 (31)	48.3 (29)	0.517
Ganglia: 8	62.5 (5)	37.5 (3)	0.317	62.5 (5)	37.5 (3)	0.481
Bone: 28	35.7 (10)	64.3 (18)	0.206	42.9 (12)	57.1 (16)	0.501
Pulmonary effusion: 31	51.6 (16)	48.4 (15)	0.413	58.1 (18)	41.9 (13)	0.271
EGFR
Wild type: 54	44.4 (24)	55.6 (30)		46.3 (25)	53.7 (29)
Mutant: 38	47.4 (18)	52.6 (20)	0.782	52.6 (20)	47.4 (18)	0.672
EGFR subtype
Exon 19 del: 26	42.3 (11)	57.7 (15)	0.686	46.2 (12)	53.8 (14)	0.819
Exon 21 L858R: 12	50.0 (6)	50.0 (6)	0.746	58.3 (7)	41.7 (5)	0.547
Exon 20 T790M: 1	100 (1)	0.0 (0)	0.273	100 (1)	0.0 (0)	0.489
ALK
Wild type: 68	51.5 (35)	48.5 (33)		54.4 (37)	45.6 (31)
Mutant: 24	29.2 (7)	70.8 (17)	0.059	33.3 (8)	66.7 (16)	0.098
TKI treatment
No: 20	55.0 (11)	45.0 (9)		55.0 (11)	45.0 (9)
Yes: 55	40.0 (22)	60.0 (33)	0.247	45.5 (25)	54.5 (30)	0.602
QT treatment
No: 61	41.0 (25)	59.0 (36)		45.9 (28)	54.1 (33)
Yes: 31	54.8 (17)	45.2 (14)	0.207	54.8 (17)	45.2 (14)	0.509
Vaccine
BNT162b2: 31	48.4 (15)	51.6 (16)		48.4 (15)	51.6 (16)
AZD1222: 36	45.9 (17)	54.1 (20)		48.6 (18)	51.4 (19)
Sputnik: 10	50.0 (5)	50.0 (5)		50.0 (5)	50.0 (5)
Sinovac: 13	38.5 (5)	61.5 (8)		46.2 (6)	53.8 (7)
Cansino: 1	0.0 (0)	100 (1)	0.864	100 (1)	0 (0)	0.895
COVID-19
No: 82	47.6 (39)	52.4 (43)		51.2 (42)	48.8 (40)
Yes: 10	30.0 (3)	70.0 (7)	0.293	30.0 (3)	70.0 (7)	0.317

* Each patient can have more than one metastatic site, resulting in a total of 157 in all 92 patients.

To enhance the clarity of the proportions described in all tables, a flow diagram was created to display the selection process of patients for ELISA and flow cytometry assays (Supplementary Figure S4).

Figure S4. Flow diagram of individuals included for analysis: CTX, chemotherapy. TKI, tyrosine kinase inhibitor. EGFR, epidermal growth factor receptor. ALK, anaplastic lymphoma kinase. CD27, cluster of differentiation 27. ASC, antibody-secreting cell. B cells, B lymphocytes.

Figure S4. Flow diagram of individuals included for analysis: CTX, chemotherapy. TKI, tyrosine kinase inhibitor. EGFR, epidermal growth factor receptor. ALK, anaplastic lymphoma kinase. CD27, cluster of differentiation 27. ASC, antibody-secreting cell. B cells, B lymphocytes.

The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.