Next Article in Journal
Dendritic Cell-Induced Th1 and Th17 Cell Differentiation for Cancer Therapy
Next Article in Special Issue
Immune System Regulation in the Induction of Broadly Neutralizing HIV-1 Antibodies
Previous Article in Journal / Special Issue
Envelope Glycoprotein Trimers as HIV-1 Vaccine Immunogens
Article Menu

Export Article

Open AccessArticle
Vaccines 2013, 1(4), 513-526;

What Has 30 Years of HIV Vaccine Research Taught Us?

Bill & Melinda Gates Foundation, PO Box 23350, Seattle, WA 98102, USA
Received: 21 August 2013 / Revised: 14 October 2013 / Accepted: 17 October 2013 / Published: 30 October 2013
(This article belongs to the Special Issue HIV Vaccines)
Full-Text   |   PDF [363 KB, uploaded 30 October 2013]


When HIV was discovered and established as the cause of AIDS in 1983–1984, many people believed that a vaccine would be rapidly developed. However, 30 years have passed and we are still struggling to develop an elusive vaccine. In trying to achieve that goal, different scientific paradigms have been explored. Although major progress has been made in understanding the scientific basis for HIV vaccine development, efficacy trials have been critical in moving the field forward. Major lessons learned are: the development of an HIV vaccine is an extremely difficult challenge; the temptation of just following the fashion should be avoided; clinical trials are critical, especially large-scale efficacy trials; HIV vaccine research will require long-term commitment; and sustainable collaborations are needed to accelerate the development of an HIV vaccine. Concrete actions must be implemented with the sense of urgency imposed by the severity of the AIDS epidemic. View Full-Text
Keywords: HIV vaccines; lessons learned; clinical trials; HIV; AIDS HIV vaccines; lessons learned; clinical trials; HIV; AIDS
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Esparza, J. What Has 30 Years of HIV Vaccine Research Taught Us? Vaccines 2013, 1, 513-526.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Vaccines EISSN 2076-393X Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top