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Hydrogen Peroxide and Redox Regulation of Developments

1
Center for Interdisciplinary Research in Biology (CIRB), College de France, CNRS, INSERM, PSL Research University, 75231 Paris, France
2
Sorbonne Paris Cité, Univ Paris Diderot, Biology Department, 75205 Paris CEDEX 13, France
3
École Normale Supérieure, Department of Biology, PSL Research University, 75005 Paris, France
*
Author to whom correspondence should be addressed.
Antioxidants 2018, 7(11), 159; https://doi.org/10.3390/antiox7110159
Received: 19 September 2018 / Revised: 10 October 2018 / Accepted: 10 October 2018 / Published: 6 November 2018
(This article belongs to the Special Issue Thioredoxin and Glutaredoxin Systems)
Reactive oxygen species (ROS), which were originally classified as exclusively deleterious compounds, have gained increasing interest in the recent years given their action as bona fide signalling molecules. The main target of ROS action is the reversible oxidation of cysteines, leading to the formation of disulfide bonds, which modulate protein conformation and activity. ROS, endowed with signalling properties, are mainly produced by NADPH oxidases (NOXs) at the plasma membrane, but their action also involves a complex machinery of multiple redox-sensitive protein families that differ in their subcellular localization and their activity. Given that the levels and distribution of ROS are highly dynamic, in part due to their limited stability, the development of various fluorescent ROS sensors, some of which are quantitative (ratiometric), represents a clear breakthrough in the field and have been adapted to both ex vivo and in vivo applications. The physiological implication of ROS signalling will be presented mainly in the frame of morphogenetic processes, embryogenesis, regeneration, and stem cell differentiation. Gain and loss of function, as well as pharmacological strategies, have demonstrated the wide but specific requirement of ROS signalling at multiple stages of these processes and its intricate relationship with other well-known signalling pathways. View Full-Text
Keywords: H2O2; redox signalling; development; regeneration; adult stem cells; metazoan H2O2; redox signalling; development; regeneration; adult stem cells; metazoan
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Rampon, C.; Volovitch, M.; Joliot, A.; Vriz, S. Hydrogen Peroxide and Redox Regulation of Developments. Antioxidants 2018, 7, 159.

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