Next Article in Journal
Effects of Spherical and Rod-like Gold Nanoparticles on the Reactivity of Human Peripheral Blood Leukocytes
Previous Article in Journal
Butein Increases Resistance to Oxidative Stress and Lifespan with Positive Effects on the Risk of Age-Related Diseases in Caenorhabditis elegans
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Antioxidants
Volume 13
Issue 2
10.3390/antiox13020156
antioxidants-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers

by
Elizabeth Córdoba-Lanús
1,2,3,*,
Luis M. Montuenga
4,5,6,7,
Angélica Domínguez-de-Barros
2,
Alexis Oliva
2,8,
Delia Mayato
9,
Ana Remírez-Sanz
5,
Francisca Gonzalvo
9,
Bartolomé Celli
10,
Javier J. Zulueta
11,† and
Ciro Casanova
1,9,12,†
1
Department of Internal Medicine, Dermatology and Psychiatry, University of La Laguna, 38296 San Cristóbal de La Laguna, Spain
2
Instituto de Enfermedades Tropicales y Salud Pública de Canarias (IUETSPC), 38029 San Cristóbal de La Laguna, Spain
3
Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain
4
Department of Pathology, Anatomy and Physiology, School of Medicine and Sciences, University of Navarra, 31008 Pamplona, Spain
5
CIMA—Centro de Investigación Médica Aplicada, University of Navarra, 31008 Pamplona, Spain
6
Navarra Institute for Health Research (IdISNA), 31008 Pamplona, Spain
7
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029 Madrid, Spain
8
Department of Pharmaceutical Technology, University of La Laguna, 38296 San Cristóbal de La Laguna, Spain
9
Pulmonary Division, Research Unit, Hospital Universitario Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
10
Pulmonary Critical Care Medicine Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
11
Pulmonary, Critical Care and Sleep Medicine Division, Mount Sinai Morningside Hospital, Icahn School of Medicine, New York, NY 10025, USA
12
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain
 
add Show full affiliation list
 
remove Hide full affiliation list
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Antioxidants 2024, 13(2), 156; https://doi.org/10.3390/antiox13020156
Submission received: 29 December 2023 / Revised: 18 January 2024 / Accepted: 23 January 2024 / Published: 26 January 2024
(This article belongs to the Section Health Outcomes of Antioxidants and Oxidative Stress)
Browse Figures
Versions Notes

Abstract

Lung cancer (LC) constitutes an important cause of death among patients with Chronic Obstructive Pulmonary Disease (COPD). Both diseases may share pathobiological mechanisms related to oxidative damage and cellular senescence. In this study, the potential value of leucocyte telomere length, a hallmark of aging, and 8-OHdG concentrations, indicative of oxidative DNA damage, as risk biomarkers of LC was evaluated in COPD patients three years prior to LC diagnosis. Relative telomere length measured using qPCR and serum levels of 8-OHdG were determined at the baseline in 99 COPD smokers (33 with LC and 66 age-matched COPD without LC as controls). Of these, 21 COPD with LC and 42 controls had the biomarkers measured 3 years before. Single nucleotide variants (SNVs) in TERT, RTEL, and NAF1 genes were also determined. COPD cases were evaluated, which showed greater telomere length (p < 0.001) and increased serum 8-OHdG levels (p = 0.004) three years prior to LC diagnosis compared to the controls. This relationship was confirmed at the time of LC diagnosis. No significant association was found between the studied SNVs in cases vs. controls. In conclusion, this preliminary study shows that longer leucocyte telomere length and increased 8-OHdG serum levels can be useful as early biomarkers of the risk for future lung cancer development among COPD patients.
Keywords: lung cancer; COPD; telomeres; oxidative stress; 8-OHdG; biomarkers lung cancer; COPD; telomeres; oxidative stress; 8-OHdG; biomarkers

Share and Cite

MDPI and ACS Style

Córdoba-Lanús, E.; Montuenga, L.M.; Domínguez-de-Barros, A.; Oliva, A.; Mayato, D.; Remírez-Sanz, A.; Gonzalvo, F.; Celli, B.; Zulueta, J.J.; Casanova, C. Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers. Antioxidants 2024, 13, 156. https://doi.org/10.3390/antiox13020156

AMA Style

Córdoba-Lanús E, Montuenga LM, Domínguez-de-Barros A, Oliva A, Mayato D, Remírez-Sanz A, Gonzalvo F, Celli B, Zulueta JJ, Casanova C. Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers. Antioxidants. 2024; 13(2):156. https://doi.org/10.3390/antiox13020156

Chicago/Turabian Style

Córdoba-Lanús, Elizabeth, Luis M. Montuenga, Angélica Domínguez-de-Barros, Alexis Oliva, Delia Mayato, Ana Remírez-Sanz, Francisca Gonzalvo, Bartolomé Celli, Javier J. Zulueta, and Ciro Casanova. 2024. "Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers" Antioxidants 13, no. 2: 156. https://doi.org/10.3390/antiox13020156

APA Style

Córdoba-Lanús, E., Montuenga, L. M., Domínguez-de-Barros, A., Oliva, A., Mayato, D., Remírez-Sanz, A., Gonzalvo, F., Celli, B., Zulueta, J. J., & Casanova, C. (2024). Oxidative Damage and Telomere Length as Markers of Lung Cancer Development among Chronic Obstructive Pulmonary Disease (COPD) Smokers. Antioxidants, 13(2), 156. https://doi.org/10.3390/antiox13020156

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop