Testicular and Haematological Cancer Induce Very High Levels of Sperm Oxidative Stress
Abstract
:1. Introduction
2. Materials and Methods
2.1. Reagents and Media
2.2. Study Population and Semen Collection
2.3. Routine Semen Analysis
2.4. Determination of Semen Oxidative Stress
2.5. Determination of sDF
2.6. Statistical Analyses
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Parameter | CP n = 123 | NSP n = 52 | HD n = 19 | p-Values | |
---|---|---|---|---|---|
Age (y) | 33.00 (27.00–37.00) | 35.00 (32.25–39.75) | 32.00 (26.00–36.00) | 0.019 1 | 0.021 2 1.00 3 0.184 4 |
Abstinence (d) | 4.00 (3.00–6.00) | 4.00 (3.00–5.38) | 3.00 (2.00–4.00) | 0.015 1 | 1.00 2 0.033 3 0.012 4 |
Volume (mL) | 3.00 (2.10–4.20) | 3.65 (2.60–4.48) | 3.50 (2.20–4.60) | 0.080 1 | |
pH | 7.60 (7.40–7.80) | 7.60 (7.40–7.75) | 7.20 (7.20–7.40) | <0.001 1 | 0.765 2 <0.001 3 <0.001 4 |
Concentration (106/mL) | 39.50 (12.00–74.30) | 112.50 (72.00–159.50) | 94.00 (47.00–102.00) | <0.001 1 | <0.001 2 0.006 3 0.693 4 |
Number (106/ejaculate) | 97.20 (40.04–224.20) | 395.80 (252.20–620.88) | 226.78 (138.56–398.25) | <0.001 1 | <0.001 2 0.004 3 0.383 4 |
Progressive Motility (%) | 42.00 (28.00–52.00) | 53.00 (46.00–61.75) | 56.00 (50.00–64.00) | <0.001 1 | <0.001 2 <0.001 3 1.00 4 |
Immotile (%) | 46.00 (38.00–58.00) | 38.00 (31.50–44.00) | 34.00 (30.00–40.00) | <0.001 1 | <0.001 2 <0.001 3 0.784 4 |
Normal Morphology (%) | 5.00 (3.00–7.00) | 6.00 (4.25–9.00) | 4.00 (4.00–3.00) | <0.001 1 | 0.004 2 0.395 3 0.002 4 |
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Calamai, C.; Ammar, O.; Rosta, V.; Farnetani, G.; Zimmitti, S.; Giovannelli, L.; Vignozzi, L.; Krausz, C.; Muratori, M. Testicular and Haematological Cancer Induce Very High Levels of Sperm Oxidative Stress. Antioxidants 2023, 12, 1145. https://doi.org/10.3390/antiox12061145
Calamai C, Ammar O, Rosta V, Farnetani G, Zimmitti S, Giovannelli L, Vignozzi L, Krausz C, Muratori M. Testicular and Haematological Cancer Induce Very High Levels of Sperm Oxidative Stress. Antioxidants. 2023; 12(6):1145. https://doi.org/10.3390/antiox12061145
Chicago/Turabian StyleCalamai, Costanza, Oumaima Ammar, Viktoria Rosta, Ginevra Farnetani, Salvatore Zimmitti, Lisa Giovannelli, Linda Vignozzi, Csilla Krausz, and Monica Muratori. 2023. "Testicular and Haematological Cancer Induce Very High Levels of Sperm Oxidative Stress" Antioxidants 12, no. 6: 1145. https://doi.org/10.3390/antiox12061145
APA StyleCalamai, C., Ammar, O., Rosta, V., Farnetani, G., Zimmitti, S., Giovannelli, L., Vignozzi, L., Krausz, C., & Muratori, M. (2023). Testicular and Haematological Cancer Induce Very High Levels of Sperm Oxidative Stress. Antioxidants, 12(6), 1145. https://doi.org/10.3390/antiox12061145