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Antioxidants
Volume 11
Issue 5
10.3390/antiox11050907
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Article

Nanoparticles Based on Cross-Linked Poly(Lipoic Acid) Protect Macrophages and Cardiomyocytes from Oxidative Stress and Ischemia Reperfusion Injury

by
Chiara Bellini
1,2,†,‡,
Salvatore Antonucci
1,†,
Lucía Morillas-Becerril
3,†,§,
Sara Scarpa
1,2,
Regina Tavano
1,2,
Fabrizio Mancin
3,
Fabio Di Lisa
1,* and
Emanuele Papini
1,2,*
1
Department of Biomedical Sciences, University of Padova, Via U. Bassi 58/b, 35121 Padova, Italy
2
CRIBI—Centre for Innovative Biotechnology Research, University of Padova, Via U. Bassi 58/b, 35121 Padova, Italy
3
Department of Chemical Sciences, University of Padova, Via F. Marzolo 1, 35121 Padova, Italy
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
‡
Current address: Hevesy György PhD School of Chemistry, Eötvös Loránd University, Pázmány Péter Sétány 1/A, 1117 Budapest, Hungary.
§
Current address: Department of Pharmaceutical Sciences, University of Milano, Via Golgi 19, 20133 Milano, Italy.
Antioxidants 2022, 11(5), 907; https://doi.org/10.3390/antiox11050907
Submission received: 5 April 2022 / Revised: 29 April 2022 / Accepted: 2 May 2022 / Published: 5 May 2022
(This article belongs to the Special Issue Applications of Antioxidant Nanoparticles)
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Abstract

The control of radical damage and oxidative stress, phenomena involved in a large number of human pathologies, is a major pharmaceutical and medical goal. We here show that two biocompatible formulations of Pluronic-stabilized, poly (lipoic acid)-based nanoparticles (NP) effectively antagonized the formation of radicals and reactive oxygen species (ROS). These NPs, not only intrinsically scavenged radicals in a-cellular DPPH/ABTS assays, but also inhibited the overproduction of ROS induced by tert-Butyl hydroperoxide (t-BHP) in tumor cells (HeLa), human macrophages and neonatal rat ventricular myocytes (NRVMs). NPs were captured by macrophages and cardiomyocytes much more effectively as compared to HeLa cells and non-phagocytic leukocytes, eventually undergoing intracellular disassembly. Notably, NPs decreased the mitochondrial ROS generation induced by simulated Ischemia/Reperfusion Injury (IRI) in isolated cardiomyocytes. NPs also prevented IRI-triggered cardiomyocyte necrosis, mitochondrial dysfunction, and alterations of contraction-related intracellular Ca2+ waves. Hence, NPs appear to be an effective and cardiomyocyte-selective drug to protect against damages induced by post-ischemic reperfusion.
Keywords: poly(lipoic acid); nanoparticles; ischemia and reperfusion injury poly(lipoic acid); nanoparticles; ischemia and reperfusion injury

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MDPI and ACS Style

Bellini, C.; Antonucci, S.; Morillas-Becerril, L.; Scarpa, S.; Tavano, R.; Mancin, F.; Di Lisa, F.; Papini, E. Nanoparticles Based on Cross-Linked Poly(Lipoic Acid) Protect Macrophages and Cardiomyocytes from Oxidative Stress and Ischemia Reperfusion Injury. Antioxidants 2022, 11, 907. https://doi.org/10.3390/antiox11050907

AMA Style

Bellini C, Antonucci S, Morillas-Becerril L, Scarpa S, Tavano R, Mancin F, Di Lisa F, Papini E. Nanoparticles Based on Cross-Linked Poly(Lipoic Acid) Protect Macrophages and Cardiomyocytes from Oxidative Stress and Ischemia Reperfusion Injury. Antioxidants. 2022; 11(5):907. https://doi.org/10.3390/antiox11050907

Chicago/Turabian Style

Bellini, Chiara, Salvatore Antonucci, Lucía Morillas-Becerril, Sara Scarpa, Regina Tavano, Fabrizio Mancin, Fabio Di Lisa, and Emanuele Papini. 2022. "Nanoparticles Based on Cross-Linked Poly(Lipoic Acid) Protect Macrophages and Cardiomyocytes from Oxidative Stress and Ischemia Reperfusion Injury" Antioxidants 11, no. 5: 907. https://doi.org/10.3390/antiox11050907

APA Style

Bellini, C., Antonucci, S., Morillas-Becerril, L., Scarpa, S., Tavano, R., Mancin, F., Di Lisa, F., & Papini, E. (2022). Nanoparticles Based on Cross-Linked Poly(Lipoic Acid) Protect Macrophages and Cardiomyocytes from Oxidative Stress and Ischemia Reperfusion Injury. Antioxidants, 11(5), 907. https://doi.org/10.3390/antiox11050907

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