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Article

Dehydro-Tocotrienol-β Counteracts Oxidative-Stress-Induced Diabetes Complications in db/db Mice

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Rolf Luft Research Center for Diabetes and Endocrinology, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-17177 Stockholm, Sweden
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Department of Molecular and Clinical Medicine, University of Gothenburg, SE-41345 Gothenburg, Sweden
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Department of Medicine, Division of Cardiology, Karolinska Institutet, SE-17177 Stockholm, Sweden
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Childhood Cancer Research Unit, Department of Women’s and Children’s Health, Karolinska Institutet, SE-17177 Stockholm, Sweden
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Institute of Biochemistry and Biophysics, Polish Academy of Sciences, PL-02-106 Warsaw, Poland
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Department of Clinical Pharmacology, Karolinska University Hospital, SE-17177 Stockholm, Sweden
*
Author to whom correspondence should be addressed.
Academic Editor: Branca M. Silva
Antioxidants 2021, 10(7), 1070; https://doi.org/10.3390/antiox10071070
Received: 16 May 2021 / Revised: 24 June 2021 / Accepted: 29 June 2021 / Published: 2 July 2021
Hyperglycemia, hyperlipidemia, and adiposity are the main factors that cause inflammation in type 2 diabetes due to excessive ROS production, leading to late complications. To counteract the effects of increased free radical production, we searched for a compound with effective antioxidant properties that can induce coenzyme Q biosynthesis without affecting normal cellular functions. Tocotrienols are members of the vitamin E family, well-known as efficient antioxidants that are more effective than tocopherols. Deh-T3β is a modified form of the naturally occurring tocotrienol-β. The synthesis of this compound involves the sequential modification of geranylgeraniol. In this study, we investigated the effects of this compound in different experimental models of diabetes complications. Deh-T3β was found to possess multifaceted capacities. In addition to enhanced wound healing, deh-T3β improved kidney and liver functions, reduced liver steatosis, and improved heart recovery after ischemia and insulin sensitivity in adipose tissue in a mice model of type 2 diabetes. Deh-T3β exerts these positive effects in several organs of the diabetic mice without reducing the non-fasting blood glucose levels, suggesting that both its antioxidant properties and improvement in mitochondrial function are involved, which are central to reducing diabetes complications. View Full-Text
Keywords: coenzyme Q; antioxidants; tocotrienol; diabetes; oxidative stress; diabetes complications; wound healing coenzyme Q; antioxidants; tocotrienol; diabetes; oxidative stress; diabetes complications; wound healing
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MDPI and ACS Style

Dallner, G.; Bentinger, M.; Hussain, S.; Sinha, I.; Yang, J.; Schwank-Xu, C.; Zheng, X.; Swiezewska, E.; Brismar, K.; Valladolid-Acebes, I.; Tekle, M. Dehydro-Tocotrienol-β Counteracts Oxidative-Stress-Induced Diabetes Complications in db/db Mice. Antioxidants 2021, 10, 1070. https://doi.org/10.3390/antiox10071070

AMA Style

Dallner G, Bentinger M, Hussain S, Sinha I, Yang J, Schwank-Xu C, Zheng X, Swiezewska E, Brismar K, Valladolid-Acebes I, Tekle M. Dehydro-Tocotrienol-β Counteracts Oxidative-Stress-Induced Diabetes Complications in db/db Mice. Antioxidants. 2021; 10(7):1070. https://doi.org/10.3390/antiox10071070

Chicago/Turabian Style

Dallner, Gustav, Magnus Bentinger, Shafaat Hussain, Indranil Sinha, Jiangning Yang, Cheng Schwank-Xu, Xiaowei Zheng, Ewa Swiezewska, Kerstin Brismar, Ismael Valladolid-Acebes, and Michael Tekle. 2021. "Dehydro-Tocotrienol-β Counteracts Oxidative-Stress-Induced Diabetes Complications in db/db Mice" Antioxidants 10, no. 7: 1070. https://doi.org/10.3390/antiox10071070

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