Next Article in Journal
Implication of Dietary Iron-Chelating Bioactive Compounds in Molecular Mechanisms of Oxidative Stress-Induced Cell Ageing
Next Article in Special Issue
Untargeted Metabolomics and Antioxidant Capacities of Muscadine Grape Genotypes during Berry Development
Previous Article in Journal
NAC and Vitamin D Restore CNS Glutathione in Endotoxin-Sensitized Neonatal Hypoxic-Ischemic Rats
Previous Article in Special Issue
Effect of Nanoconfinement of Polyphenolic Extract from Grape Pomace into Functionalized Mesoporous Silica on Its Biocompatibility and Radical Scavenging Activity
Article

Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex

1
Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, Tokyo 180-8633, Japan
2
Hyogo Prefectural Institute of Technology, 3-1-12 Yukihira-cho, Suma, Kobe 654-0037, Japan
*
Authors to whom correspondence should be addressed.
Academic Editors: Carla Pereira and Lillian Barros
Antioxidants 2021, 10(3), 490; https://doi.org/10.3390/antiox10030490
Received: 4 March 2021 / Revised: 17 March 2021 / Accepted: 18 March 2021 / Published: 20 March 2021
(This article belongs to the Collection Advances in Antioxidant Ingredients from Natural Products)
Development of a novel antioxidant-delivery vehicle exerting biosafety has been attracting a great deal of interest. In this study, a vehicle comprising a natural composite consisting of vitamin E (α-tocopherol; Toc) and cyclodextrin (CD) additives was developed, directed toward aqua-related biological applications. Not only β-CD, but also γ-CD, tended to form a water-insoluble aggregate with Toc in aqueous media. The aggregated vehicle, in particular the γ-CD-added system, showed a remarkable sustained effect because of slow dynamics. Furthermore, a prominent cytoprotective effect by the γ-CD–Toc vehicle under the oxidative stress condition was confirmed. Thus, the novel vitamin E vehicle motif using γ-CD as a stabilizer was proposed, widening the usability of Toc for biological applications. View Full-Text
Keywords: vitamin E; γ-cyclodextrin; vehicle; radical scavenging; oxidative stress; cell viability vitamin E; γ-cyclodextrin; vehicle; radical scavenging; oxidative stress; cell viability
Show Figures

Figure 1

MDPI and ACS Style

Ogawa, S.; Shinkawa, M.; Hirase, R.; Tsubomura, T.; Iuchi, K.; Hara, S. Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex. Antioxidants 2021, 10, 490. https://doi.org/10.3390/antiox10030490

AMA Style

Ogawa S, Shinkawa M, Hirase R, Tsubomura T, Iuchi K, Hara S. Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex. Antioxidants. 2021; 10(3):490. https://doi.org/10.3390/antiox10030490

Chicago/Turabian Style

Ogawa, Shigesaburo, Mai Shinkawa, Ryuji Hirase, Taro Tsubomura, Katsuya Iuchi, and Setsuko Hara. 2021. "Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex" Antioxidants 10, no. 3: 490. https://doi.org/10.3390/antiox10030490

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop