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The Impact of Unbalanced Maternal Nutritional Intakes on Oocyte Mitochondrial Activity: Implications for Reproductive Function

1
Clinica Valle Giulia, GeneraLife IVF Centers, 00197 Rome, Italy
2
Genera Veneto, GeneraLife IVF Centers, 36063 Marostica, Italy
3
Catholic University of the Sacred Heart, 20123 Rome, Italy
*
Author to whom correspondence should be addressed.
Antioxidants 2021, 10(1), 91; https://doi.org/10.3390/antiox10010091
Received: 30 November 2020 / Revised: 30 December 2020 / Accepted: 7 January 2021 / Published: 11 January 2021
(This article belongs to the Special Issue Mitochondria Biology in Reproductive Function)
Accumulating evidence on the effect of nutrition on reproduction is emerging from both animal and human studies. A healthy dietary pattern and nutrient supplementation, especially during the peri-conceptional period, might be helpful to achieve a live birth, although the mechanisms implicated are not fully understood. The endocrine system and the ooplasmic organelles apparatus, in particular the mitochondria, are clearly key elements during oogenesis and subsequent embryo development, and their proper functioning is associated with nutrition, even beyond maternal aging. Several studies in animal models have reported various adverse effects on mitochondria caused by unbalanced dietary intakes such as high fat diet, high fat high sugar diet, and low protein diet. The alterations produced might include mitochondrial intracellular distribution, content, structure, biogenesis, and functioning. This review summarizes the key role of mitochondria in female reproduction and the effects of different dietary macronutrient compositions on oocyte mitochondrial activity with their possible short-, medium-, and long-term effects. View Full-Text
Keywords: diet; nutrition; mitochondria; oocytes; reproductive competence; developmental diet; nutrition; mitochondria; oocytes; reproductive competence; developmental
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MDPI and ACS Style

Fabozzi, G.; Iussig, B.; Cimadomo, D.; Vaiarelli, A.; Maggiulli, R.; Ubaldi, N.; Ubaldi, F.M.; Rienzi, L. The Impact of Unbalanced Maternal Nutritional Intakes on Oocyte Mitochondrial Activity: Implications for Reproductive Function. Antioxidants 2021, 10, 91. https://doi.org/10.3390/antiox10010091

AMA Style

Fabozzi G, Iussig B, Cimadomo D, Vaiarelli A, Maggiulli R, Ubaldi N, Ubaldi FM, Rienzi L. The Impact of Unbalanced Maternal Nutritional Intakes on Oocyte Mitochondrial Activity: Implications for Reproductive Function. Antioxidants. 2021; 10(1):91. https://doi.org/10.3390/antiox10010091

Chicago/Turabian Style

Fabozzi, Gemma; Iussig, Benedetta; Cimadomo, Danilo; Vaiarelli, Alberto; Maggiulli, Roberta; Ubaldi, Nicolò; Ubaldi, Filippo M.; Rienzi, Laura. 2021. "The Impact of Unbalanced Maternal Nutritional Intakes on Oocyte Mitochondrial Activity: Implications for Reproductive Function" Antioxidants 10, no. 1: 91. https://doi.org/10.3390/antiox10010091

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