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Natural Food Supplements Reduce Oxidative Stress in Primary Neurons and in the Mouse Brain, Suggesting Applications in the Prevention of Neurodegenerative Diseases

Oncology Area, Center for Biomedical Research of La Rioja (CIBIR), 26006 Logroño, Spain
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Antioxidants 2021, 10(1), 46; https://doi.org/10.3390/antiox10010046
Received: 4 December 2020 / Revised: 23 December 2020 / Accepted: 24 December 2020 / Published: 2 January 2021
(This article belongs to the Special Issue Dietary Polyphenols and Neuroprotection)
Neurodegenerative diseases pose a major health problem for developed countries, and stress has been identified as one of the main risk factors in the development of these disorders. Here, we have examined the protective properties against oxidative stress of several bioactive natural food supplements. We found that MecobalActive®, Olews®, and red and white grape seed polyphenol extracts may have a neuroprotective effect in vitro, both in the SH-SY 5Y cell line and in hippocampal neuron cultures, mainly by reducing reactive oxygen species levels and decreasing caspase-3 activity. In vivo, we demonstrated that oral administration of the supplements reduces the expression of genes involved in inflammation and oxidation mechanisms, whereas it increments the expression of genes related to protection against oxidative stress. Furthermore, we found that preventive treatment with these natural extracts increases the activity of antioxidant enzymes and prevents lipid peroxidation in the brain of stressed mice. Thus, our results indicate that some natural bioactive supplements may have important protective properties against oxidative stress processes occurring in the brain. View Full-Text
Keywords: oxidative stress; ROS; neurodegenerative diseases; red grape polyphenol extract; white grape seed polyphenol extract; MecobalActive®; Olews® oxidative stress; ROS; neurodegenerative diseases; red grape polyphenol extract; white grape seed polyphenol extract; MecobalActive®; Olews®
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MDPI and ACS Style

Bobadilla, M.; García-Sanmartín, J.; Martínez, A. Natural Food Supplements Reduce Oxidative Stress in Primary Neurons and in the Mouse Brain, Suggesting Applications in the Prevention of Neurodegenerative Diseases. Antioxidants 2021, 10, 46. https://doi.org/10.3390/antiox10010046

AMA Style

Bobadilla M, García-Sanmartín J, Martínez A. Natural Food Supplements Reduce Oxidative Stress in Primary Neurons and in the Mouse Brain, Suggesting Applications in the Prevention of Neurodegenerative Diseases. Antioxidants. 2021; 10(1):46. https://doi.org/10.3390/antiox10010046

Chicago/Turabian Style

Bobadilla, Miriam, Josune García-Sanmartín, and Alfredo Martínez. 2021. "Natural Food Supplements Reduce Oxidative Stress in Primary Neurons and in the Mouse Brain, Suggesting Applications in the Prevention of Neurodegenerative Diseases" Antioxidants 10, no. 1: 46. https://doi.org/10.3390/antiox10010046

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