Next Article in Journal
Assessment and Management of HIV-Associated Cognitive Impairment: Experience from a Multidisciplinary Memory Service for People Living with HIV
Previous Article in Journal
Dunn’s Model of Sensory Processing: An Investigation of the Axes of the Four-Quadrant Model in Healthy Adults
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview

Shared Neural Correlates Underlying Addictive Disorders and Negative Urgency

Department of Psychology, Indiana University–Purdue University Indianapolis, Indianapolis, IN 46202, USA
Author to whom correspondence should be addressed.
Brain Sci. 2019, 9(2), 36;
Received: 31 January 2019 / Accepted: 6 February 2019 / Published: 8 February 2019
PDF [324 KB, uploaded 18 February 2019]


Negative urgency is a personality trait reflecting the tendency to act rashly in response to extreme negative emotions and is considered a transdiagnostic endophenotype for problematic levels of addictive behaviors. Recent research has begun to identify the neural correlates of negative urgency, many of which appear to overlap with neural circuitry underlying addictive disorders associated with negative urgency. The goal of this qualitative review is to summarize the extant literature concerning the neural correlates of negative urgency, to compare these correlates with those implicated with addictive disorders, and to propose new ways to begin to leverage such findings in treatment and intervention approaches. We also address current limitations in the field and make recommendations for areas for future growth in this research domain. Patterns of structure and function in the ventral striatum, frontal regions, such as the prefrontal cortex (PFC) and orbitofrontal cortex (OFC), and amygdala are common across addictive disorders and are related to both real-world risky behaviors and self-report measures of negative urgency. We propose that the time has come to move past considering this trait and these disorders as completely separate entities, and instead for the field to consider how general patterns of convergence across these disorders can lead to a more transdiagnostic approach to treatment and intervention. We suggest future work utilize these convergent patterns in the development of animal models of negative urgency, in the identification and testing of prime pharmacological and physiological interventions, and as objective biomarkers to be used when testing behavioral, pharmacological, and physiological intervention effectiveness. Little empirical work has been done to date in these areas and advances in these nascent fields would advance understanding and applications of the neuroscience of negative urgency. View Full-Text
Keywords: negative urgency; addictive disorders; substance use disorders; pathological gambling; disordered eating negative urgency; addictive disorders; substance use disorders; pathological gambling; disordered eating
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Um, M.; Whitt, Z.T.; Revilla, R.; Hunton, T.; Cyders, M.A. Shared Neural Correlates Underlying Addictive Disorders and Negative Urgency. Brain Sci. 2019, 9, 36.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top