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Brain Sci. 2017, 7(10), 129;

Neural Hyperexcitability in Autism Spectrum Disorders

Department of Psychiatry, University of Texas Southwestern, Dallas, TX 75390, USA
Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH 45220, USA
Author to whom correspondence should be addressed.
Received: 5 September 2017 / Revised: 29 September 2017 / Accepted: 5 October 2017 / Published: 13 October 2017
(This article belongs to the Special Issue Autism Spectrum Disorder: From Etio-Pathology to Treatment)
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Despite the progress that has been made in research on autism spectrum disorders (ASD), the understanding of the biological basis of ASD to identify targets for novel, effective treatment remains limited. One of the leading biological theories of autism is a model of cortical hyperexcitability. While numerous genetic and epigenetic studies support this model, how this particular biological alteration relates to known phenotypes in ASD is not well established. Using examples of sensory processing alterations, this review illustrates how cortical excitability may affect neural processes to result eventually in some core clinical phenotypes in ASD. Applications of the cortical excitability model for translational research and drug development are also discussed. View Full-Text
Keywords: autism; sensory abnormalities; inhibition; individual differences; sensory hypersensitivity; sensory hyposensitivity autism; sensory abnormalities; inhibition; individual differences; sensory hypersensitivity; sensory hyposensitivity

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Takarae, Y.; Sweeney, J. Neural Hyperexcitability in Autism Spectrum Disorders. Brain Sci. 2017, 7, 129.

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