Role of Vagus Nerve Stimulation in Refractory and Super Refractory Status Epilepticus: A Pediatric Case Series
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Sex | Diagnosis | Age | Time Onset-to-implant (days) | RSE Stop | Latency to SE Resolution (days) | Stimulation Parameters (at SE Resolution) | Follow Up | McHugh Score | Level of Function | Outcome | Adverse Events due to VNS | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Pt1 | F | Left Hemimegalencephaly | 16 mo | 18 | Yes | 4 | 1 mA, 500 usec, 30 Hz, DC 10% | 9 ys | IA | Unable to speak Tetraparesis | Alive | No |
Pt1 | M | NonKetotic Hyperglycinemia | 16 mo | 5 | Yes | 5 | 1 mA, 500 usec, 30 Hz, DC 10% | 8 ys | IA | n/a | Deceased for metabolic cause | No |
Pt3 | F | Microdeletion of 1q43q44 | 17 mo | 16 | Yes | 3 | 1 mA, 250 usec, 30 Hz, DC 10% | 7 ys | IA | Unable to walk Profound mental retardation | Alive | No |
Pt4 | M | Migrating Epilepsy | 7 mo | 90 | No | n/a | n/a | 1 mo | V | n/a | Deceased during RSE | No |
Pt5 | F | FIRES | 14 ys | 43 | Yes | 28 | 2.25 mA, 250 usec, 30 Hz, DC 16% | 1 y | IA | Mild neuropsych impairment | Alive | Tachycardia Coughing |
Pt6 | M | FIRES | 6 ys | 26 | Yes | 28 | 2.00 mA, 250 usec, 20 Hz, DC 15% | 1 y | IA | Behavioral problems | Alive | No |
Pt7 | F | FIRES | 6 ys | 25 | No | n/a | n/a | 4 mo | IIIB | n/a | Alive | No |
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Furlanis, G.M.; Favaro, J.; Bresolin, N.; Grioni, D.; Baro, V.; D’Amico, A.; Sartori, S.; Denaro, L.; Landi, A. Role of Vagus Nerve Stimulation in Refractory and Super Refractory Status Epilepticus: A Pediatric Case Series. Brain Sci. 2023, 13, 1589. https://doi.org/10.3390/brainsci13111589
Furlanis GM, Favaro J, Bresolin N, Grioni D, Baro V, D’Amico A, Sartori S, Denaro L, Landi A. Role of Vagus Nerve Stimulation in Refractory and Super Refractory Status Epilepticus: A Pediatric Case Series. Brain Sciences. 2023; 13(11):1589. https://doi.org/10.3390/brainsci13111589
Chicago/Turabian StyleFurlanis, Giulia Melinda, Jacopo Favaro, Nicola Bresolin, Daniele Grioni, Valentina Baro, Alberto D’Amico, Stefano Sartori, Luca Denaro, and Andrea Landi. 2023. "Role of Vagus Nerve Stimulation in Refractory and Super Refractory Status Epilepticus: A Pediatric Case Series" Brain Sciences 13, no. 11: 1589. https://doi.org/10.3390/brainsci13111589