White Matter Microstructural Alterations in Newly Diagnosed Parkinson’s Disease: A Whole-Brain Analysis Using dMRI
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. MRI Data Acquisition
2.3. Image Processing
2.4. Classification of Brain Structures
2.5. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Group | HC (n = 44) | PD (n = 44) | p-Value |
---|---|---|---|
Age (mean ± SD) | 60.4 ± 9.6 | 58.3 ± 9.3 | 0.316 |
Sex (male/female) | 27/17 | 27/17 | - |
Dominant side (left/right) | - | 23/21 | - |
Education years (mean ± SD) | 16.2 ± 2.9 | 15.3 ± 3.1 | 0.186 |
Age onset in years (mean ± SD) | - | 56.6 ± 9.7 | - |
Duration of disease in months (mean ± SD) | - | 6.1 ± 6.4 | - |
H & Y scale (mean ± SD) | 0.0 ± 0.0 | 1.5 ± 0.5 | <0.001 |
MDS-UPDRS III score (mean ± SD) | 0.7 ± 1.1 | 19.7 ± 9.1 | <0.001 |
UPSIT score (mean ± SD) | 33.3 ± 4.8 | 23.7 ± 6.9 | <0.001 |
SCOPA-AUT score (mean ± SD) | 5.4 ± 2.7 | 8.7 ± 5.7 | <0.001 |
RBDSQ score (mean ± SD) | 2.6 ± 2.0 | 3.6 ± 2.0 | 0.017 |
GDS score (mean ± SD) | 1.2 ± 2.5 | 1.8 ± 1.7 | 0.154 |
MoCA score (mean ± SD) | 28.4 ± 1.1 | 28.0 ± 1.7 | 0.188 |
Region | Subregion | HC QA (Mean ± SD) | PD QA (Mean ± SD) | p1 Value | p2 Value |
---|---|---|---|---|---|
Basal ganglia | 0.361 ± 0.031 | 0.417 ± 0.103 (M) | 0.001 | 0.002 | |
0.418 ± 0.095 (L) | <0.001 | <0.001 | |||
Striatum | 0.329 ± 0.030 | 0.385 ± 0.086 (M) | <0.001 | <0.001 | |
0.383 ± 0.093 (L) | <0.001 | <0.001 | |||
Limbic system | 0.234 ± 0.020 | 0.263 ± 0.054 (M) | 0.002 | 0.002 | |
0.263 ± 0.053 (L) | 0.001 | 0.002 | |||
Cingulate gyrus | 0.209 ± 0.018 | 0.228 ± 0.043 (M) | 0.008 | 0.004 | |
0.229 ± 0.047 (L) | 0.011 | 0.005 | |||
Cerebellum | 0.343 ± 0.029 | 0.389 ± 0.094 (M) | 0.003 | 0.003 | |
0.386 ± 0.092 (L) | 0.002 | 0.003 | |||
Thalamus | 0.398 ± 0.038 | 0.454 ± 0.130 (M) | 0.008 | 0.004 | |
0.422 ± 0.111 (L) | 0.003 | 0.003 | |||
Brain stem | 0.474 ± 0.044 | 0.551 ± 0.149 | 0.002 | 0.003 | |
Corpus callosum | 0.811 ± 0.081 | 0.901 ± 0.193 | 0.006 | 0.004 |
Region | HC QA (Mean ± SD) | PD QA (Mean ± SD) | p1 Value | p2 Value |
---|---|---|---|---|
Frontal lobe | 0.164 ± 0.018 | 0.186 ± 0.048 (M) | 0.007 | 0.004 |
0.186 ± 0.045 (L) | 0.004 | 0.004 | ||
Parietal lobe | 0.164 ± 0.022 | 0.179 ± 0.037 (M) | 0.030 | 0.005 |
0.178 ± 0.040 (L) | 0.043 | 0.005 | ||
Occipital lobe | 0.158 ± 0.018 | 0.179 ± 0.041 (M) | 0.002 | 0.003 |
0.179 ± 0.041 (L) | 0.003 | 0.003 | ||
Temporal lobe | 0.197 ± 0.018 | 0.227 ± 0.055 (M) | 0.001 | 0.001 |
0.230 ± 0.059 (L) | <0.001 | <0.001 | ||
Insular lobe | 0.231 ± 0.021 | 0.262 ± 0.056 (M) | <0.001 | 0.001 |
0.261 ± 0.055 (L) | 0.002 | 0.002 |
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Kim, J.-Y.; Shim, J.-H.; Baek, H.-M. White Matter Microstructural Alterations in Newly Diagnosed Parkinson’s Disease: A Whole-Brain Analysis Using dMRI. Brain Sci. 2022, 12, 227. https://doi.org/10.3390/brainsci12020227
Kim J-Y, Shim J-H, Baek H-M. White Matter Microstructural Alterations in Newly Diagnosed Parkinson’s Disease: A Whole-Brain Analysis Using dMRI. Brain Sciences. 2022; 12(2):227. https://doi.org/10.3390/brainsci12020227
Chicago/Turabian StyleKim, Jun-Yeop, Jae-Hyuk Shim, and Hyeon-Man Baek. 2022. "White Matter Microstructural Alterations in Newly Diagnosed Parkinson’s Disease: A Whole-Brain Analysis Using dMRI" Brain Sciences 12, no. 2: 227. https://doi.org/10.3390/brainsci12020227