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Article

Auditory Beat Stimulation Modulates Memory-Related Single-Neuron Activity in the Human Medial Temporal Lobe

1
Department of Epileptology, Venusberg-Campus 1, University Hospital Bonn, 53127 Bonn, Germany
2
Faculty of Psychology, Swiss Distance University Institute, Ueberlandstr. 12, 3900 Brig, Switzerland
3
Department of Neurosurgery, Venusberg-Campus 1, University Hospital Bonn, 53127 Bonn, Germany
4
Centre for Human Brain Health, School of Psychology, University of Birmingham, Birmingham B15 2TT, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Brian Coffman
Brain Sci. 2021, 11(3), 364; https://doi.org/10.3390/brainsci11030364
Received: 4 December 2020 / Revised: 26 February 2021 / Accepted: 10 March 2021 / Published: 12 March 2021
(This article belongs to the Special Issue Quantitative EEG and Cognitive Neuroscience)
Auditory beats are amplitude-modulated signals (monaural beats) or signals that subjectively cause the perception of an amplitude modulation (binaural beats). We investigated the effects of monaural and binaural 5 Hz beat stimulation on neural activity and memory performance in neurosurgical patients performing an associative recognition task. Previously, we had reported that these beat stimulation conditions modulated memory performance in opposite directions. Here, we analyzed data from a patient subgroup, in which microwires were implanted in the amygdala, hippocampus, entorhinal cortex and parahippocampal cortex. We identified neurons responding with firing rate changes to binaural versus monaural 5 Hz beat stimulation. In these neurons, we correlated the differences in firing rates for binaural versus monaural beats to the memory-related differences for remembered versus forgotten items and associations. In the left hemisphere, we detected statistically significant negative correlations between firing rate differences for binaural versus monaural beats and remembered versus forgotten items/associations. Importantly, such negative correlations were also observed between beat stimulation-related firing rate differences in the pre-stimulus window and memory-related firing rate differences in the post-stimulus windows. In line with concepts of homeostatic plasticity, our findings suggest that beat stimulation is linked to memory performance via shifting baseline firing levels. View Full-Text
Keywords: long-term memory; microwire recordings; item recognition; source recognition; binaural beats; monaural beats long-term memory; microwire recordings; item recognition; source recognition; binaural beats; monaural beats
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MDPI and ACS Style

Derner, M.; Chaieb, L.; Dehnen, G.; Reber, T.P.; Borger, V.; Surges, R.; Staresina, B.P.; Mormann, F.; Fell, J. Auditory Beat Stimulation Modulates Memory-Related Single-Neuron Activity in the Human Medial Temporal Lobe. Brain Sci. 2021, 11, 364. https://doi.org/10.3390/brainsci11030364

AMA Style

Derner M, Chaieb L, Dehnen G, Reber TP, Borger V, Surges R, Staresina BP, Mormann F, Fell J. Auditory Beat Stimulation Modulates Memory-Related Single-Neuron Activity in the Human Medial Temporal Lobe. Brain Sciences. 2021; 11(3):364. https://doi.org/10.3390/brainsci11030364

Chicago/Turabian Style

Derner, Marlene; Chaieb, Leila; Dehnen, Gert; Reber, Thomas P.; Borger, Valeri; Surges, Rainer; Staresina, Bernhard P.; Mormann, Florian; Fell, Juergen. 2021. "Auditory Beat Stimulation Modulates Memory-Related Single-Neuron Activity in the Human Medial Temporal Lobe" Brain Sci. 11, no. 3: 364. https://doi.org/10.3390/brainsci11030364

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