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Article

Prepulse Inhibition in Cocaine Addiction and Dual Pathologies

1
TXP Research Group, Universidad Cardenal Herrera-CEU, CEU Universities, 12006 Castellón, Spain
2
Predepartamental Unit of Medicine, Universitat Jaume I, 12071 Castellón, Spain
3
Psychiatry Department, Consorcio Hospitalario Provincial de Castellón, 12002 Castellón, Spain
4
Torrente Mental Health Centre, Hospital General Universitario, 46014 Valencia, Spain
5
Molecular Biopathology Department, Consorcio Hospitalario Provincial de Castellón, 12002 Castellón, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Joanna Jacobus
Brain Sci. 2021, 11(2), 269; https://doi.org/10.3390/brainsci11020269
Received: 19 January 2021 / Revised: 7 February 2021 / Accepted: 16 February 2021 / Published: 20 February 2021
(This article belongs to the Section Systems Neuroscience)
Cocaine addiction is frequently associated with different psychiatric disorders, especially schizophrenia and antisocial personality disorder. A small number of studies have used prepulse inhibition (PPI) as a discriminating factor between these disorders. This work evaluated PPI and the phenotype of patients with cocaine-related disorder (CRD) who presented a dual diagnosis of schizophrenia or antisocial personality disorder. A total of 74 men aged 18–60 years were recruited for this research. The sample was divided into four groups: CRD (n = 14), CRD and schizophrenia (n = 21), CRD and antisocial personality disorder (n = 16), and a control group (n = 23). We evaluated the PPI and other possible vulnerability factors in these patients by using different assessment scales. PPI was higher in the CRD group at 30 ms (F(3, 64) = 2.972, p = 0.038). Three discriminant functions were obtained which allowed us to use the overall Hare Psychopathy Checklist Revised score, reward sensitivity, and PPI at 30 ms to predict inclusion of these patients in the different groups with a success rate of 79.7% (42.9% for CRD, 76.2% for CRD and schizophrenia, 100% for CRD and antisocial personality disorder, and 91.3% in the control group). Despite the differences we observed in PPI, this factor is of little use for discriminating between the different diagnostic groups and it acts more as a non-specific endophenotype in certain mental disorders, such as in patients with a dual diagnosis. View Full-Text
Keywords: dual diagnosis; schizophrenia; antisocial personality disorder; cocaine-related disorder; psychopathy; prepulse inhibition dual diagnosis; schizophrenia; antisocial personality disorder; cocaine-related disorder; psychopathy; prepulse inhibition
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MDPI and ACS Style

Gil-Miravet, I.; Fuertes-Saiz, A.; Benito, A.; Almodóvar, I.; Ochoa, E.; Haro, G. Prepulse Inhibition in Cocaine Addiction and Dual Pathologies. Brain Sci. 2021, 11, 269. https://doi.org/10.3390/brainsci11020269

AMA Style

Gil-Miravet I, Fuertes-Saiz A, Benito A, Almodóvar I, Ochoa E, Haro G. Prepulse Inhibition in Cocaine Addiction and Dual Pathologies. Brain Sciences. 2021; 11(2):269. https://doi.org/10.3390/brainsci11020269

Chicago/Turabian Style

Gil-Miravet, Isis, Alejandro Fuertes-Saiz, Ana Benito, Isabel Almodóvar, Enrique Ochoa, and Gonzalo Haro. 2021. "Prepulse Inhibition in Cocaine Addiction and Dual Pathologies" Brain Sciences 11, no. 2: 269. https://doi.org/10.3390/brainsci11020269

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