Next Article in Journal
Heart Rate Variability and Decision-Making: Autonomic Responses in Making Decisions
Previous Article in Journal
Diagnostic, Surgical, and Technical Considerations for Lumbar Interbody Fusion in Patients with Osteopenia and Osteoporosis: A Systematic Review
 
 
Article

The Impact of Intermittent Fasting on Brain-Derived Neurotrophic Factor, Neurotrophin 3, and Rat Behavior in a Rat Model of Type 2 Diabetes Mellitus

1
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
2
Radiological Sciences Department, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
3
Department of Physiology, College of Medicine and Health Sciences, Sultan Qaboos University, P.O. Box 35, Al Koudh, Muscat PC 123, Oman
4
Department of Physiology, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia
5
Medical Physiology Department, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt
*
Author to whom correspondence should be addressed.
Academic Editor: Giovanna Paolone
Brain Sci. 2021, 11(2), 242; https://doi.org/10.3390/brainsci11020242
Received: 1 December 2020 / Revised: 25 January 2021 / Accepted: 10 February 2021 / Published: 15 February 2021
(This article belongs to the Section Behavioral Neuroscience)
Type 2 diabetes mellitus (T2DM) is known to be associated with an increased risk of dementia, specifically Alzheimer’s disease and vascular dementia. Intermittent fasting (IF) has been proposed to produce neuroprotective effects through the activation of several signaling pathways. In this study, we investigated the effect of IF on rat behavior in type 2 diabetic rats. Forty male Wistar Kyoto rats were divided into four groups (n = 10 for each): the ad libitum (Ad) group, the intermittent fasting group (IF), the streptozotocin-induced diabetic 2 group (T2DM) fed a high-fat diet for 4 weeks followed by a single intraperitoneal (i.p.) injection of streptozotocin (STZ) 25 mg kg−1, and the diabetic group with intermittent fasting (T2DM+IF). We evaluated the impact of 3 months of IF (16 h of food deprivation daily) on the levels of brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT3), serotonin, dopamine, and glutamate in the hippocampus, and rat behavior was assessed by the forced swim test and elevated plus maze. IF for 12 weeks significantly increased (p < 0.05) the levels of NT3 and BDNF in both control and T2DM rats. Additionally, it increased serotonin, dopamine, and glutamic acid in diabetic rats. Moreover, IF modulated glucose homeostasis parameters, with a significant decrease (p < 0.05) in insulin resistance and downregulation of serum corticosterone level. Interestingly, T2DM rats showed a significant increase in anxiety and depression behaviors, which were ameliorated by IF. These findings suggest that IF could produce a potentially protective effect by increasing the levels of BDNF and NT3 in both control and T2DM rats. IF could be considered as an additional therapy for depression, anxiety, and neurodegenerative diseases. View Full-Text
Keywords: intermittent fasting; BDNF; neurotrophin 3; behavior intermittent fasting; BDNF; neurotrophin 3; behavior
Show Figures

Figure 1

MDPI and ACS Style

Elesawy, B.H.; Raafat, B.M.; Muqbali, A.A.; Abbas, A.M.; Sakr, H.F. The Impact of Intermittent Fasting on Brain-Derived Neurotrophic Factor, Neurotrophin 3, and Rat Behavior in a Rat Model of Type 2 Diabetes Mellitus. Brain Sci. 2021, 11, 242. https://doi.org/10.3390/brainsci11020242

AMA Style

Elesawy BH, Raafat BM, Muqbali AA, Abbas AM, Sakr HF. The Impact of Intermittent Fasting on Brain-Derived Neurotrophic Factor, Neurotrophin 3, and Rat Behavior in a Rat Model of Type 2 Diabetes Mellitus. Brain Sciences. 2021; 11(2):242. https://doi.org/10.3390/brainsci11020242

Chicago/Turabian Style

Elesawy, Basem H., Bassem M. Raafat, Aya Al Muqbali, Amr M. Abbas, and Hussein F. Sakr. 2021. "The Impact of Intermittent Fasting on Brain-Derived Neurotrophic Factor, Neurotrophin 3, and Rat Behavior in a Rat Model of Type 2 Diabetes Mellitus" Brain Sciences 11, no. 2: 242. https://doi.org/10.3390/brainsci11020242

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop