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Case Report

Transient Complete Resolution of Tourette Syndrome Symptoms Following Personalized Depth Electrode Placement

1
Department of Neurology, Children’s Health of Orange County, Orange, CA 92868, USA
2
Department of Neurology, University of Southern California, Los Angeles, CA 90033, USA
3
Department of Neurosurgery, University of Southern California, Los Angeles, CA 90033, USA
4
Department of Neurosurgery, Children’s Hospital of Los Angeles, Los Angeles, CA 90027, USA
5
Department of Electrical Engineering and Computer Science, University of California, Irvine, CA 92697, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Giovanni Pellegrino
Brain Sci. 2021, 11(12), 1559; https://doi.org/10.3390/brainsci11121559 (registering DOI)
Received: 26 October 2021 / Revised: 23 November 2021 / Accepted: 23 November 2021 / Published: 25 November 2021
Treatment refractory Tourette syndrome has been shown to be improved with deep brain stimulation, but with multiple possible stimulation locations and variable and incomplete benefit. This study presents a single case of complete amelioration of motor and verbal tics in a patient with Tourette syndrome during placement of 12 stereo-EEG electrodes to identify optimal targets for permanent stimulating electrodes. Subsequently, substantial improvement in motor and verbal tic frequency occurred with placement and programming of permanent electrodes in bilateral globus pallidus internus and nucleus accumbens, but without the complete resolution seen during depth electrode placement. We suggest that simultaneous stimulation at multiple patient-specific targets could provide effective control of Tourette symptomatology, but further study will be needed. View Full-Text
Keywords: Tourette syndrome; deep brain stimulation; pediatric; targeting; stereo EEG Tourette syndrome; deep brain stimulation; pediatric; targeting; stereo EEG
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MDPI and ACS Style

MacLean, J.A.; Ferman, D.; Chu, J.K.; Liker, M.A.; Sanger, T.D. Transient Complete Resolution of Tourette Syndrome Symptoms Following Personalized Depth Electrode Placement. Brain Sci. 2021, 11, 1559. https://doi.org/10.3390/brainsci11121559

AMA Style

MacLean JA, Ferman D, Chu JK, Liker MA, Sanger TD. Transient Complete Resolution of Tourette Syndrome Symptoms Following Personalized Depth Electrode Placement. Brain Sciences. 2021; 11(12):1559. https://doi.org/10.3390/brainsci11121559

Chicago/Turabian Style

MacLean, Jennifer A., Diana Ferman, Jason K. Chu, Mark A. Liker, and Terence D. Sanger 2021. "Transient Complete Resolution of Tourette Syndrome Symptoms Following Personalized Depth Electrode Placement" Brain Sciences 11, no. 12: 1559. https://doi.org/10.3390/brainsci11121559

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