Infratentorial Stereotactic Biopsy of Brainstem and Cerebellar Lesions
Abstract
:1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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N | % | ||
---|---|---|---|
Gender | 190 | 100.00% | |
Female | 96 | 50.50% | |
Male | 94 | 49.50% | |
Age (years), mean ± SD | 41 | 16 | |
KPS, mean ± SD | 84 | 14 | |
Diagnosis | 190 | 100% | |
Astrocytoma grade 2 | 68 | 35.80% | |
Astrocytoma grade 3 | 37 | 19.50% | |
Lymphoma | 17 | 8.90% | |
Glioblastoma | 15 | 7.90% | |
Non-neoplastic lesion | 14 | 7.40% | |
Metastatic tumor | 10 | 5.30% | |
Non-diagnostic biopsy | 8 | 4.20% | |
NA | 5 | 2.60% | |
Ependymoma | 4 | 2.10% | |
Pilocytic astrocytoma | 4 | 2.10% | |
Posterior fossa ependymoma grade 3 | 3 | 1.60% | |
Oligodendroglioma grade 3 | 2 | 1.10% | |
Medulloblastoma | 2 | 1.10% | |
Meningioma grade 1 | 1 | 0.50% | |
Side | 117 | 100% | |
Left | 55 | 47.00% | |
Right | 50 | 42.70% | |
Both | 12 | 10.30% | |
Approach | 145 | 100% | |
Left | 76 | 52.40% | |
Right | 69 | 47.60% | |
Symptoms | 118 | 100.00% | |
Blurred vision | 49 | 41.50% | |
Balance disorders | 45 | 38.10% | |
Paresthesia | 37 | 31.30% | |
Vertigo | 33 | 27.90% | |
Paresis | 25 | 21.20% | |
Speech disorders | 21 | 17.80% | |
Headache | 14 | 11.80% | |
Epilepsy | 9 | 7.60% | |
Dysphagia | 7 | 5.90% | |
Multifocal tumors | 15 | 100% | |
Lymphoma | 6 | 40% | |
Astrocytoma grade 2 | 3 | 20% | |
Astrocytoma grade 3 | 2 | 13.30% | |
Glioblastoma | 2 | 13.30% | |
Oligodendroglioma grade 3 | 1 | 6.70% | |
Benign lesion | 1 | 6.70% | |
Complications | |||
Without complications | 179 | 94.50% | |
Non-significant intracranial bleeding on CT | 4 | 2.00% | |
Pain during biopsy | 2 | 1.00% | |
Cerebrospinal fluid leak | 1 | 0.50% | |
Temporary ataxia | 1 | 0.50% | |
Worsening of paresis | 1 | 0.50% | |
CN VII palsy | 1 | 0.50% | |
Death | 1 | 0.50% |
Location | N | % | |
---|---|---|---|
Brainstem | 60 | 31.70% | |
Pons | 22 | 11.60% | |
Brainstem | 21 | 11.10% | |
Pons + Medulla oblongata | 10 | 5.30% | |
Midbrain | 3 | 1.60% | |
Midbrain + Pons | 2 | 1.10% | |
Medulla oblongata | 1 | 0.50% | |
Midbrain + Pons + Medulla oblongata | 1 | 0.50% | |
Cerebellum | 62 | 32.70% | |
Cerebellar peduncle | 26 | 13.70% | |
Cerebellar hemisphere | 25 | 13.20% | |
Cerebellar vermis | 8 | 4.20% | |
Cerebellar hemisphere + Cerebellar vermis | 2 | 1.10% | |
Cerebellar peduncle + Cerebellar vermis | 1 | 0.50% | |
Brainstem + Cerebellum | 46 | 24.30% | |
Pons + Cerebellar peduncle | 21 | 11.10% | |
Pons + Medulla oblongata + Cerebellar peduncle | 7 | 3.70% | |
Pons + Cerebellar hemisphere | 5 | 2.60% | |
Pons + Cerebellar peduncle + Cerebellar hemisphere | 4 | 2.10% | |
Pons + Cerebellar vermis | 3 | 1.60% | |
Midbrain + Pons + Cerebellar peduncle | 2 | 1.10% | |
Pons + Cerebellar hemisphere + Cerebellar vermis | 2 | 1.10% | |
Medulla oblongata + Cerebellar peduncle | 1 | 0.50% | |
Pons + Cerebellar peduncle + Cerebellar vermis | 1 | 0.50% | |
Area of 4th ventricle | 22 | 11.60% | |
Area of 4th ventricle | 17 | 8.90% | |
Cerebellar vermis + Area of 4th ventricle | 3 | 1.60% | |
Pons + Medulla oblongata + Area of 4th ventricle | 2 | 1.10% |
IDH1 Mutation | MGMT Promoter Methylation | Codeletion of 1p19q | ||||
---|---|---|---|---|---|---|
Diagnosis | Wildtype | Mutant | Unmethylated | Methylated | Non-Codeleted | Codeleted |
Astrocytoma grade 3 | 10 | 1 | 3 | 7 | 10 | 0 |
Astrocytoma grade 2 | 8 | 2 | 5 | 5 | 10 | 0 |
Glioblastoma | 2 | 0 | 0 | 2 | 2 | 0 |
Pilocytic astrocytoma | 1 | 0 | 1 | 0 | 1 | 0 |
Grade | Pearson Chi-Square | Phi Coefficient | |||||||
---|---|---|---|---|---|---|---|---|---|
LGG | HGG | Total | Value | df | p | Value | p | ||
Toxoplasma gondii | Negative | 20 | 6 | 26 | 14.679 | 1 | <0.001 * | 0.565 | <0.001 |
Positive | 4 | 16 | 20 | ||||||
Total | 24 | 22 | 46 | ||||||
Epstein–Barr virus | Negative | 2 | 3 | 5 | 0.402 | 1 | 0.526 a | −0.94 | 0.526 |
Positive | 22 | 18 | 40 | ||||||
Total | 24 | 21 | 45 | ||||||
MRI contrast enhancement | No | 26 | 10 | 36 | 7.844 | 1 | 0.005 * | 0.313 | 0.005 |
Yes | 18 | 26 | 44 | ||||||
Total | 44 | 36 | 80 |
Infratentorial | Supratentorial | ||||
---|---|---|---|---|---|
N | % | N | % | ||
Diagnostic material for histopathological evaluation | 181/190 | 95.30% | 61/63 | 96.80% | |
Complications | |||||
Without complications | 179 | 94.50% | 62 | 98.40% | |
Non-significant intracranial bleeding on CT | 4 | 2.00% | |||
Pain during biopsy | 2 | 1.00% | 1 | 1.60% | |
Cerebrospinal fluid leak | 1 | 0.50% | |||
Temporary ataxia | 1 | 0.50% | |||
Worsening of paresis | 1 | 0.50% | |||
CN VII palsy | 1 | 0.50% | |||
Diagnostic material for molecular evaluation | 26/29 | 89.70% | 5/6 | 83.30% |
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Furtak, J.; Śledzińska, P.; Bebyn, M.G.; Szylberg, T.; Krajewski, S.; Birski, M.; Harat, M. Infratentorial Stereotactic Biopsy of Brainstem and Cerebellar Lesions. Brain Sci. 2021, 11, 1432. https://doi.org/10.3390/brainsci11111432
Furtak J, Śledzińska P, Bebyn MG, Szylberg T, Krajewski S, Birski M, Harat M. Infratentorial Stereotactic Biopsy of Brainstem and Cerebellar Lesions. Brain Sciences. 2021; 11(11):1432. https://doi.org/10.3390/brainsci11111432
Chicago/Turabian StyleFurtak, Jacek, Paulina Śledzińska, Marek G. Bebyn, Tadeusz Szylberg, Stanisław Krajewski, Marcin Birski, and Marek Harat. 2021. "Infratentorial Stereotactic Biopsy of Brainstem and Cerebellar Lesions" Brain Sciences 11, no. 11: 1432. https://doi.org/10.3390/brainsci11111432