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Med. Sci. 2017, 5(4), 21;

Quantification of Age‐Related Lung Tissue Mechanics under Mechanical Ventilation

College of Engineering, University of Georgia, 597 DW Brooks Drive, Athens, GA 30602, USA
Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA
The VCU Johnson Center, Virginia Commonwealth University Medical Center, Richmond, VA 23284, USA
Department of Mathematics & Applied Mathematics, Virginia Commonwealth University, Richmond,   VA 23284, USA
Author to whom correspondence should be addressed.
Received: 28 August 2017 / Revised: 25 September 2017 / Accepted: 28 September 2017 / Published: 29 September 2017
(This article belongs to the Section Pneumology and Respiratory Diseases)
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Elderly patients with obstructive lung diseases often receive mechanical ventilation to support their breathing and restore respiratory function. However, mechanical ventilation is known to increase the severity of ventilator‐induced lung injury (VILI) in the elderly. Therefore, it is important to investigate the effects of aging to better understand the lung tissue mechanics to estimate the severity of ventilator‐induced lung injuries. Two age‐related geometric models involving human bronchioles from generation G10 to G23 and alveolar sacs were developed. The first is for a 50‐year‐old (normal) and second is for an 80‐year old (aged) model. Lung tissue mechanics of normal and aged models were investigated under mechanical ventilation through computational simulations. Results obtained indicated that lung tissue strains during inhalation (t = 0.2 s) decreased by about 40% in the alveolar sac (G23) and 27% in the bronchiole (G20), respectively, for the 80‐year‐old as compared to the 50‐year‐old. The respiratory mechanics parameters (work of breathing per unit volume and maximum tissue strain) over G20 and G23 for the 80‐year‐old decreased by about 64% (three‐fold) and 80% (four‐fold), respectively, during the mechanical ventilation breathing cycle. However, there was a significant increase (by about threefold) in lung compliance for the 80‐year‐old in comparison to the 50‐year‐old. These findings from the computational simulations demonstrated that lung mechanical characteristics are significantly compromised in aging tissues, and these effects were quantified in this study. View Full-Text
Keywords: aging; ventilator‐induced lung injury; lung mechanics; pressure; computational models; tissue strains; tissue stress aging; ventilator‐induced lung injury; lung mechanics; pressure; computational models; tissue strains; tissue stress

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Kim, J.; Heise, R.L.; Reynolds, A.M.; Pidaparti, R.M. Quantification of Age‐Related Lung Tissue Mechanics under Mechanical Ventilation. Med. Sci. 2017, 5, 21.

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