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Diagnostics 2018, 8(1), 16;

Review of Gallium-68 PSMA PET/CT Imaging in the Management of Prostate Cancer

Nuclear Oncology, Theranostics Australia, 106/1 Silas Street, Richmond Quarter Building, East Fremantle, WA 6158, Australia
School of Medicine and Pharmacology, University of Western Australia, 35 Stirling Highway, Nedlands, WA 6009, Australia
Author to whom correspondence should be addressed.
Received: 12 December 2017 / Revised: 1 February 2018 / Accepted: 1 February 2018 / Published: 11 February 2018
(This article belongs to the Special Issue Radiopharmaceuticals for Cancer Diagnosis)
Full-Text   |   PDF [4678 KB, uploaded 14 February 2018]   |  


Over 90% of prostate cancers over-express prostate specific membrane antigen (PSMA) and these tumor cells may be accurately targeted for diagnosis by 68Ga-PSMA-positron emission tomography/computed tomography (68Ga-PSMA-PET/CT) imaging. This novel molecular imaging modality appears clinically to have superseded CT, and appears superior to MR imaging, for the detection of metastatic disease. 68Ga-PSMA PET/CT has the ability to reliably stage prostate cancer at presentation and can help inform an optimal treatment approach. Novel diagnostic applications of 68Ga-PSMA PET/CT include guiding biopsy to improve sampling accuracy, and guiding surgery and radiotherapy. In addition to facilitating the management of metastatic castrate resistant prostate cancer (mCRPC), 68Ga-PSMA can select patients who may benefit from targeted systemic radionuclide therapy. 68Ga-PSMA is the diagnostic positron-emitting theranostic pair with the beta emitter Lutetium-177 PSMA (177Lu-PSMA) and alpha-emitter Actinium-225 PSMA (225Ac-PSMA) which can both be used to treat PSMA-avid metastases of prostate cancer in the molecular tumor-targeted approach of theranostic nuclear oncology. View Full-Text
Keywords: theranostics; nuclear oncology; molecular imaging; 68Ga-PSMA PET/CT; prostate cancer theranostics; nuclear oncology; molecular imaging; 68Ga-PSMA PET/CT; prostate cancer

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Lenzo, N.P.; Meyrick, D.; Turner, J.H. Review of Gallium-68 PSMA PET/CT Imaging in the Management of Prostate Cancer. Diagnostics 2018, 8, 16.

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