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Open AccessReview

Review of Gallium-68 PSMA PET/CT Imaging in the Management of Prostate Cancer

1
Nuclear Oncology, Theranostics Australia, 106/1 Silas Street, Richmond Quarter Building, East Fremantle, WA 6158, Australia
2
School of Medicine and Pharmacology, University of Western Australia, 35 Stirling Highway, Nedlands, WA 6009, Australia
*
Author to whom correspondence should be addressed.
Diagnostics 2018, 8(1), 16; https://doi.org/10.3390/diagnostics8010016
Received: 12 December 2017 / Revised: 1 February 2018 / Accepted: 1 February 2018 / Published: 11 February 2018
(This article belongs to the Special Issue Radiopharmaceuticals for Cancer Diagnosis)
Over 90% of prostate cancers over-express prostate specific membrane antigen (PSMA) and these tumor cells may be accurately targeted for diagnosis by 68Ga-PSMA-positron emission tomography/computed tomography (68Ga-PSMA-PET/CT) imaging. This novel molecular imaging modality appears clinically to have superseded CT, and appears superior to MR imaging, for the detection of metastatic disease. 68Ga-PSMA PET/CT has the ability to reliably stage prostate cancer at presentation and can help inform an optimal treatment approach. Novel diagnostic applications of 68Ga-PSMA PET/CT include guiding biopsy to improve sampling accuracy, and guiding surgery and radiotherapy. In addition to facilitating the management of metastatic castrate resistant prostate cancer (mCRPC), 68Ga-PSMA can select patients who may benefit from targeted systemic radionuclide therapy. 68Ga-PSMA is the diagnostic positron-emitting theranostic pair with the beta emitter Lutetium-177 PSMA (177Lu-PSMA) and alpha-emitter Actinium-225 PSMA (225Ac-PSMA) which can both be used to treat PSMA-avid metastases of prostate cancer in the molecular tumor-targeted approach of theranostic nuclear oncology. View Full-Text
Keywords: theranostics; nuclear oncology; molecular imaging; 68Ga-PSMA PET/CT; prostate cancer theranostics; nuclear oncology; molecular imaging; 68Ga-PSMA PET/CT; prostate cancer
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Lenzo, N.P.; Meyrick, D.; Turner, J.H. Review of Gallium-68 PSMA PET/CT Imaging in the Management of Prostate Cancer. Diagnostics 2018, 8, 16.

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