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Diagnostics 2015, 5(1), 1-9;

Evaluation of the Diagnostic Accuracy of Serum D-Dimer Levels in Pregnant Women with Adnexal Torsion

Zekai Tahir Burak Women's Health Education and Research Hospital, 1549 Cadde, Hardem Apartmanı, B Blok, Daire 12 Çiğdem-Çankaya, Ankara 06300, Turkey
Author to whom correspondence should be addressed.
Academic Editor: Ludmilla A. Morozova-Roche
Received: 15 September 2014 / Accepted: 20 November 2014 / Published: 5 January 2015
(This article belongs to the Special Issue Biomarkers in Blood)
Full-Text   |   PDF [691 KB, uploaded 5 January 2015]


We aimed to evaluate the diagnostic accuracy of serum D-dimer levels in pregnant women with adnexal torsion (AT). The pregnant women with ovarian cysts who suffered from pelvic pain were divided into two groups; the first group consisted of the cases with surgically proven as AT (n = 17) and the second group consisted of the cases whose pain were resolved in the course of follow-up period without required surgery (n = 34). The clinical characteristics and serum D-dimer levels were compared between the groups. Patients with AT had a higher rate of elevated serum white blood cell (WBC) count (57% vs. 16%, p = 0.04) and serum D-dimer levels (77% vs. 21%, p < 0.01) on admission in the study group than in the control group. Elevated D-dimer and cyst diameter larger than 5 cm yielded highest sensitivity (82% for each); whereas the presence of nausea and vomiting and elevated CRP had the highest specificity (85% and 88%, respectively). This is the first study that evaluates the serum D-dimer levels in humans in the diagnosis of AT, and our findings supported the use of D-dimer for the early diagnosis of AT in pregnant women. View Full-Text
Keywords: adnexal torsion; D-dimer; ovarian torsion; pregnancy adnexal torsion; D-dimer; ovarian torsion; pregnancy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Topçu, H.O.; İskender, C.T.; Ceran, U.; Kaymak, O.; Timur, H.; Uygur, D.; Danışman, N. Evaluation of the Diagnostic Accuracy of Serum D-Dimer Levels in Pregnant Women with Adnexal Torsion. Diagnostics 2015, 5, 1-9.

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