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When Medicine Meets Engineering—Paradigm Shifts in Diagnostics and Therapeutics

Department of Mechanical and Aerospace Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA
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Diagnostics 2013, 3(1), 126-154; https://doi.org/10.3390/diagnostics3010126
Received: 10 December 2012 / Revised: 10 January 2013 / Accepted: 23 January 2013 / Published: 27 February 2013
(This article belongs to the Special Issue Microfluidic Lab-on-a-Chip Platforms for High-Performance Diagnostics)
During the last two decades, the manufacturing techniques of microfluidics-based devices have been phenomenally advanced, offering unlimited potential for bio-medical technologies. However, the direct applications of these technologies toward diagnostics and therapeutics are still far from maturity. The present challenges lay at the interfaces between the engineering systems and the biocomplex systems. A precisely designed engineering system with narrow dynamic range is hard to seamlessly integrate with the adaptive biological system in order to achieve the design goals. These differences remain as the roadblock between two fundamentally non-compatible systems. This paper will not extensively review the existing microfluidic sensors and actuators; rather, we will discuss the sources of the gaps for integration. We will also introduce system interface technologies for bridging the differences to lead toward paradigm shifts in diagnostics and therapeutics. View Full-Text
Keywords: microfluidic system; MEMS transducers; feedback system control (FSC); combinatorial drugs; network medicine microfluidic system; MEMS transducers; feedback system control (FSC); combinatorial drugs; network medicine
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Wang, H.; Silva, A.; Ho, C.-M. When Medicine Meets Engineering—Paradigm Shifts in Diagnostics and Therapeutics. Diagnostics 2013, 3, 126-154.

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