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Article

Risk Assessment of the Progression of Early Knee Osteoarthritis by Collagen Neoepitope C2C: A Longitudinal Study of an Estonian Middle-Aged Cohort

1
Department of Internal Medicine, Institute of Clinical Medicine, University of Tartu, 50090 Tartu, Estonia
2
Central Laboratory, Diagnostic Clinic, East-Tallinn Central Hospital, 10138 Tallinn, Estonia
3
Sports Medicine and Rehabilitation Clinic, Institute of Clinical Medicine, University of Tartu, 50090 Tartu, Estonia
*
Author to whom correspondence should be addressed.
Academic Editor: Sten Rasmussen
Diagnostics 2021, 11(7), 1236; https://doi.org/10.3390/diagnostics11071236
Received: 27 May 2021 / Revised: 29 June 2021 / Accepted: 7 July 2021 / Published: 10 July 2021
(This article belongs to the Special Issue Biomarkers in Osteoarthritis)
One of the unmet needs to be addressed is prognostic biomarkers for early knee osteoarthritis (kOA). We aimed to study the association of urinary collagen type-II C-terminal cleavage neoepitope (uC2C) with the emergence and progression of kOA. The longitudinal data of 330 subjects (aged 32–60 years) from an Estonian population-based cohort were used. The radiographic progression was evaluated by the grading system of Nagaosa et al. of knee compartments at baseline and three years later. The emerging kOA consisted of subjects with developing osteophytes or joint space narrowing, whereas kOA progressors showed aggravation of radiographic grade. Baseline uC2C levels were measured by the IBEX-uC2C assay. At baseline, the subjects were middle-aged (mean age, 47.6 years) and overweight (mean BMI, 28.0 kg/m2), and the majority of them (51.2%) had a diagnosis of kOA grade 1. Multiple logistic regression models adjusted for sex, age, and BMI were used for risk calculations. We demonstrate that increased uC2C accurately predicted the risk of emerging of kOA (OR = 5.87 (1.71–20.22); AUC = 0.79) compared with controls without radiographic kOA over 12 years. However, the most accurate prediction of progression by the biomarker was found in women (OR = 23.0 (2.2–245), AUC = 0.91). In conclusion, uC2C may be a promising candidate as a prognostic biomarker for kOA progression, particularly of emerging kOA in women. View Full-Text
Keywords: osteoarthritis; knee; osteophytes; joint space narrowing; neoepitope C2C; biomarker; prognostic osteoarthritis; knee; osteophytes; joint space narrowing; neoepitope C2C; biomarker; prognostic
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MDPI and ACS Style

Kuhi, L.; Tamm, A.E.; Tamm, A.O.; Kisand, K. Risk Assessment of the Progression of Early Knee Osteoarthritis by Collagen Neoepitope C2C: A Longitudinal Study of an Estonian Middle-Aged Cohort. Diagnostics 2021, 11, 1236. https://doi.org/10.3390/diagnostics11071236

AMA Style

Kuhi L, Tamm AE, Tamm AO, Kisand K. Risk Assessment of the Progression of Early Knee Osteoarthritis by Collagen Neoepitope C2C: A Longitudinal Study of an Estonian Middle-Aged Cohort. Diagnostics. 2021; 11(7):1236. https://doi.org/10.3390/diagnostics11071236

Chicago/Turabian Style

Kuhi, Liisa, Ann E. Tamm, Agu O. Tamm, and Kalle Kisand. 2021. "Risk Assessment of the Progression of Early Knee Osteoarthritis by Collagen Neoepitope C2C: A Longitudinal Study of an Estonian Middle-Aged Cohort" Diagnostics 11, no. 7: 1236. https://doi.org/10.3390/diagnostics11071236

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