Comparative Performance of Four Established Neonatal Disease Scoring Systems in Predicting In-Hospital Mortality and the Potential Role of Thromboelastometry
Abstract
:1. Introduction
2. Materials and Methods
Statistical Analysis
3. Results
3.1. Performance over Time of SNAP II, SNAPPE II, SNAPPE and Modified NEOMOD Score
3.2. Multivariable Models including the A10 EXTEM Parameter
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Mean ± SD; Median (IQR) or n (%) | |
---|---|
Gender (males) | 300 (63.4%) |
Gestational age (weeks) | 35.2 ± 4.37; 37 (32–39) |
Birth weight (g) | 2434 ± 983; 2580 (1480–3240) |
Cesarean section | 320 (67.7%) |
5 min APGAR score | 8.13 ± 1.54; 8 (8–9) |
Temperature (°C) | 36.9 ± 0.53; 37.0 (36.7–37.1) |
Mean blood pressure (mmHg) | 53.1 ± 9.1; 53.0 (47.0–58.0) |
Blood Ph | 7.38 ± 0.08; 7.39 (7.35–7.43) |
SNAP II | 3.87 ± 7.53; 0 (0–5) |
SNAPPE II | 7.86 ± 12.2; 5 (0–12) |
SNAPPE | 7.62 ± 10.4; 4 (1–10) |
NEOMOD score | 5.09 ± 2.99; 4 (3–7) |
Suspected sepsis | 176 (37.2%) |
Sepsis | 136 (28.8%) |
Respiratory distress syndrome | 243 (51.4%) |
Intraventricular hemorrhage | 147 (31.1%) |
Intrauterine growth retardation | 57 (12.1%) |
Perinatal hypoxia | 144 (30.4%) |
Acute renal failure | 70 (14.8%) |
Disseminated intravascular coagulopathy | 77 (16.3%) |
Periventricular leuokomalacia | 69 (14.6%) |
Seizures | 32 (6.8%) |
Necrotizing enterocolitis | 18 (3.8%) |
WBC (×103, cells/µL) | 14.5 ± 8.07; 12.9 (9.47–17.9) |
Neutrophils (%) | 58.3 ± 17.5; 60.5 (47.0–72.0) |
Platelets (×103, cells/µL) | 216 ± 136; 221 (100–295) |
Albumin (g/dL) | 2.56 ± 0.43; 2.50 (2.30–2.80) |
Hematocrit (%) | 41.1 ± 7.08; 40.9 (36.3–45.9) |
C-reactive protein (mg/L) | 33.1 ± 45.2; 13.6 (3.40–47.2) |
SGOT (IU/L) | 120 ± 397; 56.0 (34.0–92.0) |
SGPT (IU/L) | 47.7 ± 125; 19.0 (12.0–35.0) |
Total bilirubin (mg/dL) | 7.57 ± 6.63; 6.05 (3.95–9.45) |
Direct bilirubin (mg/dL) | 1.39 ± 4.39; 0.30 (0.20–0.50) |
Blood urea nitrogen (mg/dL) | 40.4 ± 35.2; 30.0 (20.0–50.0) |
Creatinine (mg/dL) | 0.66 ± 0.39; 0.60 (0.40–0.80) |
Extem ROTEMS parameters: | |
CT | 76.4 ± 294; 52.0 (45.0–63.0) |
A10 | 49.3 ± 15.3; 52.0 (41.0–60.0) |
A20 | 54.6 ± 14.8; 58.0 (47.0–65.0) |
A30 | 55.6 ± 14.5; 58.0 (48.0–65.0) |
CFT | 189 ± 521; 88.0 (62.0–140) |
MCF (mm) | 56.7 ± 15.0; 59.0 (49.0–67.0) |
ALPHA-angle | 71.5 ± 12.3; 75.0 (68.0–80.0) |
LI60 (%) | 94.5 ± 7.46; 95.0 (93.0–99.0) |
ML (%) | 10.1 ± 12.0; 8.00 (3.00–13.00) |
Time (Days) a | SNAP II | SNAPPE II | SNAPPE | Modified NEOMOD |
---|---|---|---|---|
5 | 0.724 (0.617–0.830) | 0.750 (0.638–0.863) | 0.828 (0.741–0.915) b,c | 0.858 (0.779–0.936) b,c |
15 | 0.746 (0.644–0.847) | 0.765 (0.659–0.871) | 0.818 (0.725–0.910) | 0.843 (0.757–0.929) b |
30 | 0.746 (0.656–0.837) | 0.767 (0.675–0.859) | 0.834 (0.756–0.912) b,c | 0.851 (0.780–0.921) b,c |
60 | 0.755 (0.668–0.842) | 0.783 (0.697–0.869) | 0.852 (0.780–0.925) b,c | 0.856 (0.792–0.920) b,c |
90 | 0.755 (0.668–0.842) | 0.783 (0.697–0.870) | 0.852 (0.780–0.925) b,c | 0.856 (0.791–0.920) b,c |
120 | 0.768 (0.685–0.852) | 0.796 (0.713–0.879) | 0.862 (0.793–0.930) b,c | 0.860 (0.798–0.921) b |
Time (Days) a | SNAP II | SNAPPE II | SNAPPE | Modified NEOMOD |
---|---|---|---|---|
Preterm neonates (n = 224) | ||||
5 | 0.688 (0.548–0.828) | 0.747 (0.595–0.900) | 0.815 (0.714–0.916) | 0.792 (0.664–0.921) |
15 | 0.715 (0.580–0.850) | 0.770 (0.625–0.915) | 0.834 (0.737–0.930) b | 0.806 (0.683–0.928) |
30 | 0.709 (0.591–0.828) | 0.763 (0.641–0.885) | 0.843 (0.763–0.924) b | 0.819 (0.720–0.917) |
60 | 0.694 (0.574–0.814) | 0.760 (0.641–0.879) | 0.847 (0.768–0.925) b | 0.818 (0.723–0.912) |
90 | 0.695 (0.575–0.815) | 0.761 (0.642–0.880) | 0.847 (0.769–0.926) b | 0.817 (0.722–0.912) |
120 | 0.693 (0.574–0.813) | 0.761 (0.643–0.879) | 0.849 (0.771–0.927) b | 0.820 (0.725–0.916) |
Term neonates d (n = 249) | ||||
5 | 0.827 (0.676–0.978) | 0.783 (0.612–0.954) | 0.819 (0.644–0.994) | 0.928 (0.855–0.999) b,c |
15 | 0.814 (0.666–0.962) | 0.780 (0.617–0.944) | 0.779 (0.602–0.956) | 0.865 (0.728–0.999) |
30 | 0.821 (0.688–0.954) | 0.787 (0.641–0.933) | 0.805 (0.657–0.952) | 0.868 (0.757–0.979) |
60 | 0.845 (0.731–0.959) | 0.820 (0.693–0.947) | 0.843 (0.714–0.972) | 0.881 (0.787–0.975) |
90 | 0.845 (0.731–0.959) | 0.820 (0.693–0.947) | 0.843 (0.714–0.972) | 0.881 (0.787–0.975) |
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Sokou, R.; Tritzali, M.; Piovani, D.; Konstantinidi, A.; Tsantes, A.G.; Ioakeimidis, G.; Lampridou, M.; Parastatidou, S.; Iacovidou, N.; Kokoris, S.; et al. Comparative Performance of Four Established Neonatal Disease Scoring Systems in Predicting In-Hospital Mortality and the Potential Role of Thromboelastometry. Diagnostics 2021, 11, 1955. https://doi.org/10.3390/diagnostics11111955
Sokou R, Tritzali M, Piovani D, Konstantinidi A, Tsantes AG, Ioakeimidis G, Lampridou M, Parastatidou S, Iacovidou N, Kokoris S, et al. Comparative Performance of Four Established Neonatal Disease Scoring Systems in Predicting In-Hospital Mortality and the Potential Role of Thromboelastometry. Diagnostics. 2021; 11(11):1955. https://doi.org/10.3390/diagnostics11111955
Chicago/Turabian StyleSokou, Rozeta, Maroula Tritzali, Daniele Piovani, Aikaterini Konstantinidi, Andreas G. Tsantes, Georgios Ioakeimidis, Maria Lampridou, Stavroula Parastatidou, Nicoletta Iacovidou, Styliani Kokoris, and et al. 2021. "Comparative Performance of Four Established Neonatal Disease Scoring Systems in Predicting In-Hospital Mortality and the Potential Role of Thromboelastometry" Diagnostics 11, no. 11: 1955. https://doi.org/10.3390/diagnostics11111955