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Review

Targeted Approaches for In Situ Gut Microbiome Manipulation

by 1,2,†, 2,3,†, 1,2, 1,2, 1,2, 2,3,4 and 1,2,*
1
Department of Biochemistry, Yong Loo Lin School of Medicine, 8 Medical Drive, Singapore 117596, Singapore
2
NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore
3
Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore
4
Khoo Teck Puat-National University Children’s Medical Institute, National University Health System, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore
*
Author to whom correspondence should be addressed.
Contributed equally.
Genes 2018, 9(7), 351; https://doi.org/10.3390/genes9070351
Received: 28 May 2018 / Revised: 7 July 2018 / Accepted: 9 July 2018 / Published: 12 July 2018
(This article belongs to the Special Issue Emerging Applications in Synthetic Biology)
Microbial communities and their collective genomes form the gut microbiome, of which bacteria are the major contributor. Through their secreted metabolites, bacteria interact with the host, influencing human health and physiology. Perturbation of the microbiota and metabolome has been associated with various diseases and metabolic conditions. As knowledge on fundamental host-microbiome interactions and genetic engineering tools becomes readily available, targeted manipulation of the gut microbiome for therapeutic applications gains favourable attention. Manipulation of the gut microbiome can be achieved by altering the microbiota population and composition, or by modifying the functional metabolic activity of the microbiome to promote health and restore the microbiome balance. In this article, we review current works that demonstrate various strategies employed to manipulate the gut microbiome in situ to various degrees of precision. View Full-Text
Keywords: gut microbiome; microbiome modulation; prebiotics; probiotics; phage; CRISPR-Cas9 gut microbiome; microbiome modulation; prebiotics; probiotics; phage; CRISPR-Cas9
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MDPI and ACS Style

Lee, H.L.; Shen, H.; Hwang, I.Y.; Ling, H.; Yew, W.S.; Lee, Y.S.; Chang, M.W. Targeted Approaches for In Situ Gut Microbiome Manipulation. Genes 2018, 9, 351. https://doi.org/10.3390/genes9070351

AMA Style

Lee HL, Shen H, Hwang IY, Ling H, Yew WS, Lee YS, Chang MW. Targeted Approaches for In Situ Gut Microbiome Manipulation. Genes. 2018; 9(7):351. https://doi.org/10.3390/genes9070351

Chicago/Turabian Style

Lee, Hui L., Haosheng Shen, In Y. Hwang, Hua Ling, Wen S. Yew, Yung S. Lee, and Matthew W. Chang 2018. "Targeted Approaches for In Situ Gut Microbiome Manipulation" Genes 9, no. 7: 351. https://doi.org/10.3390/genes9070351

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