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Genes 2018, 9(7), 351; https://doi.org/10.3390/genes9070351

Targeted Approaches for In Situ Gut Microbiome Manipulation

1
Department of Biochemistry, Yong Loo Lin School of Medicine, 8 Medical Drive, Singapore 117596, Singapore
2
NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore
3
Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore
4
Khoo Teck Puat-National University Children’s Medical Institute, National University Health System, 5 Lower Kent Ridge Rd, Singapore 119074, Singapore
Contributed equally.
*
Author to whom correspondence should be addressed.
Received: 28 May 2018 / Revised: 7 July 2018 / Accepted: 9 July 2018 / Published: 12 July 2018
(This article belongs to the Special Issue Emerging Applications in Synthetic Biology)
Full-Text   |   PDF [1002 KB, uploaded 12 July 2018]   |  

Abstract

Microbial communities and their collective genomes form the gut microbiome, of which bacteria are the major contributor. Through their secreted metabolites, bacteria interact with the host, influencing human health and physiology. Perturbation of the microbiota and metabolome has been associated with various diseases and metabolic conditions. As knowledge on fundamental host-microbiome interactions and genetic engineering tools becomes readily available, targeted manipulation of the gut microbiome for therapeutic applications gains favourable attention. Manipulation of the gut microbiome can be achieved by altering the microbiota population and composition, or by modifying the functional metabolic activity of the microbiome to promote health and restore the microbiome balance. In this article, we review current works that demonstrate various strategies employed to manipulate the gut microbiome in situ to various degrees of precision. View Full-Text
Keywords: gut microbiome; microbiome modulation; prebiotics; probiotics; phage; CRISPR-Cas9 gut microbiome; microbiome modulation; prebiotics; probiotics; phage; CRISPR-Cas9
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Lee, H.L.; Shen, H.; Hwang, I.Y.; Ling, H.; Yew, W.S.; Lee, Y.S.; Chang, M.W. Targeted Approaches for In Situ Gut Microbiome Manipulation. Genes 2018, 9, 351.

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