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Open AccessArticle

The Complete Genome of Brucella Suis 019 Provides Insights on Cross-Species Infection

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College of Medicine, Shihezi University, Xinjiang 832000, China
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Co-Innovation Center for Zoonotic Infectious Diseases in the western region, Shihezi University, Xinjiang 832000, China
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College of Animal Science and Technology, Shihezi University, Xinjiang 832000, China
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College of Life Sciences, Nankai University, Tianjin 300071, China
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College of Life Sciences, Shihezi University, Xinjiang 832000, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Selvarangan Ponnazhagan
Received: 29 October 2015 / Revised: 13 January 2016 / Accepted: 19 January 2016 / Published: 26 January 2016
Brucella species are the most important zoonotic pathogens worldwide and cause considerable harm to humans and animals. In this study, we presented the complete genome of B. suis 019 isolated from sheep (ovine) with epididymitis. B. suis 019 has a rough phenotype and can infect sheep, rhesus monkeys and possibly humans. The comparative genome analysis demonstrated that B. suis 019 is closest to the vaccine strain B. suis bv. 1 str. S2. Further analysis associated the rsh gene to the pathogenicity of B. suis 019, and the WbkA gene to the rough phenotype of B. suis 019. The 019 complete genome data was deposited in the GenBank database with ID PRJNA308608. View Full-Text
Keywords: Brucella; B. suis 019; complete genome; cross species; comparative genomics Brucella; B. suis 019; complete genome; cross species; comparative genomics
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MDPI and ACS Style

Wang, Y.; Wang, Z.; Chen, X.; Zhang, H.; Guo, F.; Zhang, K.; Feng, H.; Gu, W.; Wu, C.; Ma, L.; Li, T.; Chen, C.; Gao, S. The Complete Genome of Brucella Suis 019 Provides Insights on Cross-Species Infection. Genes 2016, 7, 7.

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