Modeling of the SV40 DNA Replication Machine
Abstract
:Abbreviations
OBD | origin binding domain |
DH | double hexamer |
pol/prim | polymerase alpha/primase |
RPA | replication protein A |
ssDNA | single-stranded DNA |
dsDNA | double-stranded DNA |
1. Introduction
2. Experimental Section
3. Results and Discussion
3.1. The Origin Binding Domain Double Hexamer
3.2. Structure of theDouble Hexamer
3.3. Mechanism of DNA Unwinding
3.4. RPA-DH Structure
3.5. Placement of Topoisomerase I at the C Terminal Regions
3.6. Placement of Part of pol/prim on the RPA/Topo I/T DH
3.7. Position of the J Domain and Topo I at N Terminal Regions
3.8. What Doesn’t Work
4. Conclusions
Supplementary Materials
Acknowledgements
References
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Simmons, D.T. Modeling of the SV40 DNA Replication Machine. Genes 2012, 3, 742-758. https://doi.org/10.3390/genes3040742
Simmons DT. Modeling of the SV40 DNA Replication Machine. Genes. 2012; 3(4):742-758. https://doi.org/10.3390/genes3040742
Chicago/Turabian StyleSimmons, Daniel T. 2012. "Modeling of the SV40 DNA Replication Machine" Genes 3, no. 4: 742-758. https://doi.org/10.3390/genes3040742
APA StyleSimmons, D. T. (2012). Modeling of the SV40 DNA Replication Machine. Genes, 3(4), 742-758. https://doi.org/10.3390/genes3040742