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The Rate and Tract Length of Gene Conversion between Duplicated Genes

Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193, Japan
PRESTO, Japan Science and Technology Agency (JST), Saitama, 332-0012, Japan
Author to whom correspondence should be addressed.
Genes 2011, 2(2), 313-331;
Received: 17 February 2011 / Revised: 11 March 2011 / Accepted: 17 March 2011 / Published: 25 March 2011
(This article belongs to the Special Issue Gene Conversion in Duplicated Genes)
PDF [642 KB, uploaded 25 March 2011]


Interlocus gene conversion occurs such that a certain length of DNA fragment is non-reciprocally transferred (copied and pasted) between paralogous regions. To understand the rate and tract length of gene conversion, there are two major approaches. One is based on mutation-accumulation experiments, and the other uses natural DNA sequence variation. In this review, we overview the two major approaches and discuss their advantages and disadvantages. In addition, to demonstrate the importance of statistical analysis of empirical and evolutionary data for estimating tract length, we apply a maximum likelihood method to several data sets. View Full-Text
Keywords: interlocus gene conversion; tract length; gene conversion rate interlocus gene conversion; tract length; gene conversion rate
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Mansai, S.P.; Kado, T.; Innan, H. The Rate and Tract Length of Gene Conversion between Duplicated Genes. Genes 2011, 2, 313-331.

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