Next Article in Journal
Old and New Systemic Immune-Inflammation Indexes Are Associated with Overall Survival of Glioblastoma Patients Treated with Radio-Chemotherapy
Previous Article in Journal
Genome-Wide Association Mapping of Grain Metal Accumulation in Wheat
 
 
Article

Potential Influence of Age and Diabetes Mellitus Type 1 on MSH2 (MutS homolog 2) Expression in a Rat Kidney Tissue

1
Department of Medicine, University Hospital Dubrava, 10 000 Zagreb, Croatia
2
Department of Anatomy, Histology and Embryology, University of Split School of Medicine, 21 000 Split, Croatia
3
Center for Applied Bioanthropology, Institute for Anthropological Research, 10 000 Zagreb, Croatia
4
Center for Evidence-Based Medicine, Catholic University of Croatia, 10 000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Academic Editor: Thangiah Geetha
Genes 2022, 13(6), 1053; https://doi.org/10.3390/genes13061053
Received: 19 May 2022 / Revised: 7 June 2022 / Accepted: 9 June 2022 / Published: 13 June 2022
(This article belongs to the Section Molecular Genetics and Genomics)
Background: Homeostasis of proliferating tissues is strongly dependent on intact DNA. Both neoplastic and non-neoplastic diseases have been associated with MSH2 (MutS homolog 2, a mismatch repair protein) deficiency. In this study, we examined how age and diabetes mellitus influence the expression of MSH2 in the kidney. Methods: To study the effect of age, three groups of healthy rats were formed: 2 months, 8 months, and 14 months old. Two groups of diabetic rats were formed: 8 months old and 14 months old. Expression of MSH2 in the kidney was studied by quantifying immunofluorescent staining. Results: Age was identified as the main factor that influences MSH2 expression in kidneys. The effect of age followed parabolic dynamics, with peak expression at 8 months of age and similar levels at 2 and 14 months. Diabetes had an age-dependent effect, which manifested as the increase of MSH2 expression in 14-month-old diabetic rats in comparison to healthy animals. Conclusions: Age influences MSH2 expression in the kidney more than diabetes mellitus. Since ageing is a risk factor for kidney neoplasia, downregulation of MSH2 in older rats might represent one of the pro-oncogenic mechanisms of ageing at a molecular level. View Full-Text
Keywords: MSH2; diabetes mellitus; kidney MSH2; diabetes mellitus; kidney
Show Figures

Graphical abstract

MDPI and ACS Style

Babić, P.; Filipović, N.; Hamzić, L.F.; Puljak, L.; Vukojević, K.; Benzon, B. Potential Influence of Age and Diabetes Mellitus Type 1 on MSH2 (MutS homolog 2) Expression in a Rat Kidney Tissue. Genes 2022, 13, 1053. https://doi.org/10.3390/genes13061053

AMA Style

Babić P, Filipović N, Hamzić LF, Puljak L, Vukojević K, Benzon B. Potential Influence of Age and Diabetes Mellitus Type 1 on MSH2 (MutS homolog 2) Expression in a Rat Kidney Tissue. Genes. 2022; 13(6):1053. https://doi.org/10.3390/genes13061053

Chicago/Turabian Style

Babić, Paško, Natalija Filipović, Lejla Ferhatović Hamzić, Livia Puljak, Katarina Vukojević, and Benjamin Benzon. 2022. "Potential Influence of Age and Diabetes Mellitus Type 1 on MSH2 (MutS homolog 2) Expression in a Rat Kidney Tissue" Genes 13, no. 6: 1053. https://doi.org/10.3390/genes13061053

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop