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Review

Post-Translational Modification of MRE11: Its Implication in DDR and Diseases

by 1,†, 2,†, 1, 3,4, 5,* and 1,*
1
School of Medicine, Sun Yat-Sen University, Shenzhen 518107, China
2
Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College; Kunming 650118, China
3
Leibniz Institute on Aging–Fritz Lipmann Institute (FLI), 07745 Jena, Germany
4
Faculty of Biological Sciences, Friedrich-Schiller-University of Jena, 07745 Jena, Germany
5
School of Public Health (Shenzhen), Sun Yat-Sen University, Shenzhen 518107, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Junya Kobayashi and Robert Brosh
Genes 2021, 12(8), 1158; https://doi.org/10.3390/genes12081158
Received: 30 June 2021 / Revised: 21 July 2021 / Accepted: 24 July 2021 / Published: 28 July 2021
Maintaining genomic stability is vital for cells as well as individual organisms. The meiotic recombination-related gene MRE11 (meiotic recombination 11) is essential for preserving genomic stability through its important roles in the resection of broken DNA ends, DNA damage response (DDR), DNA double-strand breaks (DSBs) repair, and telomere maintenance. The post-translational modifications (PTMs), such as phosphorylation, ubiquitination, and methylation, regulate directly the function of MRE11 and endow MRE11 with capabilities to respond to cellular processes in promptly, precisely, and with more diversified manners. Here in this paper, we focus primarily on the PTMs of MRE11 and their roles in DNA response and repair, maintenance of genomic stability, as well as their association with diseases such as cancer. View Full-Text
Keywords: MRE11; PTM; DDR; disease MRE11; PTM; DDR; disease
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MDPI and ACS Style

Lu, R.; Zhang, H.; Jiang, Y.-N.; Wang, Z.-Q.; Sun, L.; Zhou, Z.-W. Post-Translational Modification of MRE11: Its Implication in DDR and Diseases. Genes 2021, 12, 1158. https://doi.org/10.3390/genes12081158

AMA Style

Lu R, Zhang H, Jiang Y-N, Wang Z-Q, Sun L, Zhou Z-W. Post-Translational Modification of MRE11: Its Implication in DDR and Diseases. Genes. 2021; 12(8):1158. https://doi.org/10.3390/genes12081158

Chicago/Turabian Style

Lu, Ruiqing, Han Zhang, Yi-Nan Jiang, Zhao-Qi Wang, Litao Sun, and Zhong-Wei Zhou. 2021. "Post-Translational Modification of MRE11: Its Implication in DDR and Diseases" Genes 12, no. 8: 1158. https://doi.org/10.3390/genes12081158

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