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Embryonic Kidney Development, Stem Cells and the Origin of Wilms Tumor

by 1, 2 and 1,3,*
1
Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, FIN-00014 Helsinki, Finland
2
Department of Human Genetics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
3
GM-Unit, Laboratory Animal Center, Helsinki Institute of Life Science, University of Helsinki, FIN-00014 Helsinki, Finland
*
Author to whom correspondence should be addressed.
Academic Editor: Simona Chera
Genes 2021, 12(2), 318; https://doi.org/10.3390/genes12020318
Received: 27 January 2021 / Revised: 17 February 2021 / Accepted: 18 February 2021 / Published: 23 February 2021
The adult mammalian kidney is a poorly regenerating organ that lacks the stem cells that could replenish functional homeostasis similarly to, e.g., skin or the hematopoietic system. Unlike a mature kidney, the embryonic kidney hosts at least three types of lineage-specific stem cells that give rise to (a) a ureter and collecting duct system, (b) nephrons, and (c) mesangial cells together with connective tissue of the stroma. Extensive interest has been raised towards these embryonic progenitor cells, which are normally lost before birth in humans but remain part of the undifferentiated nephrogenic rests in the pediatric renal cancer Wilms tumor. Here, we discuss the current understanding of kidney-specific embryonic progenitor regulation in the innate environment of the developing kidney and the types of disruptions in their balanced regulation that lead to the formation of Wilms tumor. View Full-Text
Keywords: kidney; organogenesis; pediatric cancer; stem cells; differentiation; self-renewal kidney; organogenesis; pediatric cancer; stem cells; differentiation; self-renewal
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MDPI and ACS Style

Li, H.; Hohenstein, P.; Kuure, S. Embryonic Kidney Development, Stem Cells and the Origin of Wilms Tumor. Genes 2021, 12, 318. https://doi.org/10.3390/genes12020318

AMA Style

Li H, Hohenstein P, Kuure S. Embryonic Kidney Development, Stem Cells and the Origin of Wilms Tumor. Genes. 2021; 12(2):318. https://doi.org/10.3390/genes12020318

Chicago/Turabian Style

Li, Hao, Peter Hohenstein, and Satu Kuure. 2021. "Embryonic Kidney Development, Stem Cells and the Origin of Wilms Tumor" Genes 12, no. 2: 318. https://doi.org/10.3390/genes12020318

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