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10.3390/genes12020237
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Article

Identification of Common Pathogenetic Processes between Schizophrenia and Diabetes Mellitus by Systems Biology Analysis

by
Md Rezanur Rahman
1,2,
Tania Islam
2,
Ferdinando Nicoletti
3,*,
Maria Cristina Petralia
4,
Rosella Ciurleo
4,
Francesco Fisicaro
3,
Manuela Pennisi
3,
Alessia Bramanti
4,
Talip Yasir Demirtas
5,
Esra Gov
5,
Md Rafiqul Islam
6,7,
Bashair M. Mussa
8,
Mohammad Ali Moni
9 and
Paolo Fagone
3
1
Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia 7003, Bangladesh
2
Department of Biochemistry and Biotechnology, Khwaja Yunus Ali University, Enayetpur, Sirajganj 6751, Bangladesh
3
Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy
4
IRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy
5
Department of Bioengineering, Faculty of Engineering, Adana Alparslan Turkes Science and Technology University, Adana 01250, Turkey
6
School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, QLD 4059, Australia
7
Department of Pharmacy, Faculty of Biological Science and Technology, Jashore University of Science and Technology, Jashore 7408, Bangladesh
8
Basic Medical Sciences Department, College of Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates
9
WHO Collaborating Centre on eHealth, UNSW Digital Health, School of Public Health and Community Medicine, Faculty of Medicine, Sydney, NSW 2052, Australia
*
Author to whom correspondence should be addressed.
Genes 2021, 12(2), 237; https://doi.org/10.3390/genes12020237
Submission received: 2 December 2020 / Revised: 2 February 2021 / Accepted: 4 February 2021 / Published: 7 February 2021
(This article belongs to the Special Issue Genetics of Psychiatric Disease and the Basics of Neurobiology)
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Abstract

Schizophrenia (SCZ) is a psychiatric disorder characterized by both positive symptoms (i.e., psychosis) and negative symptoms (such as apathy, anhedonia, and poverty of speech). Epidemiological data show a high likelihood of early onset of type 2 diabetes mellitus (T2DM) in SCZ patients. However, the molecular processes that could explain the epidemiological association between SCZ and T2DM have not yet been characterized. Therefore, in the present study, we aimed to identify underlying common molecular pathogenetic processes and pathways between SCZ and T2DM. To this aim, we analyzed peripheral blood mononuclear cell (PBMC) transcriptomic data from SCZ and T2DM patients, and we detected 28 differentially expressed genes (DEGs) commonly modulated between SCZ and T2DM. Inflammatory-associated processes and membrane trafficking pathways as common biological processes were found to be in common between SCZ and T2DM. Analysis of the putative transcription factors involved in the regulation of the DEGs revealed that STAT1 (Signal Transducer and Activator of Transcription 1), RELA (v-rel reticuloendotheliosis viral oncogene homolog A (avian)), NFKB1 (Nuclear Factor Kappa B Subunit 1), and ERG (ETS-related gene) are involved in the expression of common DEGs in SCZ and T2DM. In conclusion, we provide core molecular signatures and pathways that are shared between SCZ and T2DM, which may contribute to the epidemiological association between them.
Keywords: schizophrenia; type 2 diabetes mellitus; differentially expressed genes; pathways; transcription factors schizophrenia; type 2 diabetes mellitus; differentially expressed genes; pathways; transcription factors

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MDPI and ACS Style

Rahman, M.R.; Islam, T.; Nicoletti, F.; Petralia, M.C.; Ciurleo, R.; Fisicaro, F.; Pennisi, M.; Bramanti, A.; Demirtas, T.Y.; Gov, E.; et al. Identification of Common Pathogenetic Processes between Schizophrenia and Diabetes Mellitus by Systems Biology Analysis. Genes 2021, 12, 237. https://doi.org/10.3390/genes12020237

AMA Style

Rahman MR, Islam T, Nicoletti F, Petralia MC, Ciurleo R, Fisicaro F, Pennisi M, Bramanti A, Demirtas TY, Gov E, et al. Identification of Common Pathogenetic Processes between Schizophrenia and Diabetes Mellitus by Systems Biology Analysis. Genes. 2021; 12(2):237. https://doi.org/10.3390/genes12020237

Chicago/Turabian Style

Rahman, Md Rezanur, Tania Islam, Ferdinando Nicoletti, Maria Cristina Petralia, Rosella Ciurleo, Francesco Fisicaro, Manuela Pennisi, Alessia Bramanti, Talip Yasir Demirtas, Esra Gov, and et al. 2021. "Identification of Common Pathogenetic Processes between Schizophrenia and Diabetes Mellitus by Systems Biology Analysis" Genes 12, no. 2: 237. https://doi.org/10.3390/genes12020237

APA Style

Rahman, M. R., Islam, T., Nicoletti, F., Petralia, M. C., Ciurleo, R., Fisicaro, F., Pennisi, M., Bramanti, A., Demirtas, T. Y., Gov, E., Islam, M. R., Mussa, B. M., Moni, M. A., & Fagone, P. (2021). Identification of Common Pathogenetic Processes between Schizophrenia and Diabetes Mellitus by Systems Biology Analysis. Genes, 12(2), 237. https://doi.org/10.3390/genes12020237

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