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Article

Genomewide Association Analyses of Lactation Persistency and Milk Production Traits in Holstein Cattle Based on Imputed Whole-Genome Sequence Data

1
Department of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA
2
Department of Animal Sciences, State University of Ponta Grossa, Ponta Grossa 84030-900, Brazil
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Centre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, ON N1G2W1, Canada
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Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science & Technology, Sichuan Agricultural University, Chengdu 611130, China
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Department of Animal and Food Science, University of Wisconsin River Falls, River Falls, WI 54022, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Juan-Jose Arranz
Genes 2021, 12(11), 1830; https://doi.org/10.3390/genes12111830
Received: 30 October 2021 / Revised: 13 November 2021 / Accepted: 17 November 2021 / Published: 19 November 2021
(This article belongs to the Special Issue Genome-Wide Association Analysis of Cattle)
Lactation persistency and milk production are among the most economically important traits in the dairy industry. In this study, we explored the association of over 6.1 million imputed whole-genome sequence variants with lactation persistency (LP), milk yield (MILK), fat yield (FAT), fat percentage (FAT%), protein yield (PROT), and protein percentage (PROT%) in North American Holstein cattle. We identified 49, 3991, 2607, 4459, 805, and 5519 SNPs significantly associated with LP, MILK, FAT, FAT%, PROT, and PROT%, respectively. Various known associations were confirmed while several novel candidate genes were also revealed, including ARHGAP35, NPAS1, TMEM160, ZC3H4, SAE1, ZMIZ1, PPIF, LDB2, ABI3, SERPINB6, and SERPINB9 for LP; NIM1K, ZNF131, GABRG1, GABRA2, DCHS1, and SPIDR for MILK; NR6A1, OLFML2A, EXT2, POLD1, GOT1, and ETV6 for FAT; DPP6, LRRC26, and the KCN gene family for FAT%; CDC14A, RTCA, HSTN, and ODAM for PROT; and HERC3, HERC5, LALBA, CCL28, and NEURL1 for PROT%. Most of these genes are involved in relevant gene ontology (GO) terms such as fatty acid homeostasis, transporter regulator activity, response to progesterone and estradiol, response to steroid hormones, and lactation. The significant genomic regions found contribute to a better understanding of the molecular mechanisms related to LP and milk production in North American Holstein cattle. View Full-Text
Keywords: dairy cattle; extended lactation; genetic variants; genomewide association study; GWAS; QTL dairy cattle; extended lactation; genetic variants; genomewide association study; GWAS; QTL
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MDPI and ACS Style

Pedrosa, V.B.; Schenkel, F.S.; Chen, S.-Y.; Oliveira, H.R.; Casey, T.M.; Melka, M.G.; Brito, L.F. Genomewide Association Analyses of Lactation Persistency and Milk Production Traits in Holstein Cattle Based on Imputed Whole-Genome Sequence Data. Genes 2021, 12, 1830. https://doi.org/10.3390/genes12111830

AMA Style

Pedrosa VB, Schenkel FS, Chen S-Y, Oliveira HR, Casey TM, Melka MG, Brito LF. Genomewide Association Analyses of Lactation Persistency and Milk Production Traits in Holstein Cattle Based on Imputed Whole-Genome Sequence Data. Genes. 2021; 12(11):1830. https://doi.org/10.3390/genes12111830

Chicago/Turabian Style

Pedrosa, Victor B., Flavio S. Schenkel, Shi-Yi Chen, Hinayah R. Oliveira, Theresa M. Casey, Melkaye G. Melka, and Luiz F. Brito. 2021. "Genomewide Association Analyses of Lactation Persistency and Milk Production Traits in Holstein Cattle Based on Imputed Whole-Genome Sequence Data" Genes 12, no. 11: 1830. https://doi.org/10.3390/genes12111830

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