Next Article in Journal
Of Drugs and Trypanosomatids: New Tools and Knowledge to Reduce Bottlenecks in Drug Discovery
Previous Article in Journal
Cardiac Transcriptome Analysis Reveals Nr4a1 Mediated Glucose Metabolism Dysregulation in Response to High-Fat Diet
Open AccessArticle

The Potential Effect of Aberrant Testosterone Levels on Common Diseases: A Mendelian Randomization Study

1
Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China
2
Shanghai Center for Women and Children’s Health, 339 Luding Road, Shanghai 200062, China
*
Author to whom correspondence should be addressed.
Genes 2020, 11(7), 721; https://doi.org/10.3390/genes11070721
Received: 8 June 2020 / Revised: 21 June 2020 / Accepted: 26 June 2020 / Published: 29 June 2020
(This article belongs to the Section Human Genomics and Genetic Diseases)
Testosterone has historically been linked to sexual dysfunction; however, it has recently been shown to affect other physical and mental attributes. We attempted to determine whether changes in serum testosterone could play a role in chronic or degenerative diseases. We used two separate genetic instruments comprising of variants from JMJD1C and SHBG regions and conducted a two-sample Mendelian randomization for type II diabetes (T2D), gout, rheumatoid arthritis (RA), schizophrenia, bipolar disorder, Alzheimer’s disease and depression. For the JMJD1C locus, one unit increase in log transformed testosterone was significantly associated with RA (OR = 1.69, p = 0.02), gout (OR = 0.469, p = 0.001) and T2D (OR = 0.769, p = 0.048). Similarly, one unit increase in log transformed testosterone using variants from the SHBG locus was associated with depression (OR = 1.02, p < 0.0001), RA (OR = 1.254, p < 0.0001) and T2D (OR = 0.88, p < 0.0001). Our results show that low levels of serum testosterone levels may cause gout and T2D, while higher than normal levels of testosterone may result in RA and depression. Our findings suggest that fluctuations in testosterone levels may have severe consequences that warrant further investigation. View Full-Text
Keywords: Mendelian randomization (MR); testosterone; schizophrenia (SCZ); Alzheimer’s disorder (AD); type II diabetes (T2D); gout Mendelian randomization (MR); testosterone; schizophrenia (SCZ); Alzheimer’s disorder (AD); type II diabetes (T2D); gout
Show Figures

Figure 1

MDPI and ACS Style

Syed, A.A.S.; He, L.; Shi, Y. The Potential Effect of Aberrant Testosterone Levels on Common Diseases: A Mendelian Randomization Study. Genes 2020, 11, 721.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop