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Article

The Reversion of cg05575921 Methylation in Smoking Cessation: A Potential Tool for Incentivizing Healthy Aging

1
Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USA
2
Behavioral Diagnostics LLC, Coralville, IA 52241, USA
3
Department of Biostatistics, University of Iowa, Iowa City, IA 52242, USA
4
Department of Radiology, University of Iowa, Iowa City, IA 52242, USA
5
Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
6
Molecular Medicine Program, University of Iowa, Iowa City, IA 52242, USA
7
Center for Access & Delivery Research and Evaluation, Iowa City VA Health Care System, Iowa City, IA 52242, USA
*
Author to whom correspondence should be addressed.
Genes 2020, 11(12), 1415; https://doi.org/10.3390/genes11121415
Received: 18 October 2020 / Revised: 18 November 2020 / Accepted: 24 November 2020 / Published: 27 November 2020
(This article belongs to the Special Issue Genetic and Environmental Factors in Ageing and Age-Related Disease)
Smoking is the largest preventable cause of mortality and the largest environmental driver of epigenetic aging. Contingency management-based strategies can be used to treat smoking but require objective methods of verifying quitting status. Prior studies have suggested that cg05575921 methylation reverts as a function of smoking cessation, but that it can be used to verify the success of smoking cessation has not been unequivocally demonstrated. To test whether methylation can be used to verify cessation, we determined monthly cg05575921 levels in a group of 67 self-reported smokers undergoing biochemically monitored contingency management-based smoking cessation therapy, as part of a lung imaging protocol. A total of 20 subjects in this protocol completed three months of cotinine verified smoking cessation. In these 20 quitters, the reversion of cg05575921 methylation was dependent on their initial smoking intensity, with methylation levels in the heaviest smokers reverting to an average of 0.12% per day over the 3-month treatment period. In addition, we found suggestive evidence that some individuals may have embellished their smoking history to gain entry to the study. Given the prominent effect of smoking on longevity, we conclude that DNA methylation may be a useful tool for guiding and incentivizing contingency management-based approaches for smoking cessation. View Full-Text
Keywords: smoking cessation; contingency management; DNA methylation; AHRR; cg05575921 smoking cessation; contingency management; DNA methylation; AHRR; cg05575921
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MDPI and ACS Style

Philibert, R.; Mills, J.A.; Long, J.D.; Salisbury, S.E.; Comellas, A.; Gerke, A.; Dawes, K.; Vander Weg, M.; Hoffman, E.A. The Reversion of cg05575921 Methylation in Smoking Cessation: A Potential Tool for Incentivizing Healthy Aging. Genes 2020, 11, 1415. https://doi.org/10.3390/genes11121415

AMA Style

Philibert R, Mills JA, Long JD, Salisbury SE, Comellas A, Gerke A, Dawes K, Vander Weg M, Hoffman EA. The Reversion of cg05575921 Methylation in Smoking Cessation: A Potential Tool for Incentivizing Healthy Aging. Genes. 2020; 11(12):1415. https://doi.org/10.3390/genes11121415

Chicago/Turabian Style

Philibert, Robert, James A. Mills, Jeffrey D. Long, Sue E. Salisbury, Alejandro Comellas, Alicia Gerke, Kelsey Dawes, Mark Vander Weg, and Eric A. Hoffman. 2020. "The Reversion of cg05575921 Methylation in Smoking Cessation: A Potential Tool for Incentivizing Healthy Aging" Genes 11, no. 12: 1415. https://doi.org/10.3390/genes11121415

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