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Overexpression of HMGA1 Figures as a Potential Prognostic Factor in Endometrioid Endometrial Carcinoma (EEC)

1
Programa de Carcinogênese Molecular, Instituto Nacional de Câncer—INCA, Rua André Cavalcanti, 37 - Centro, Rio de Janeiro, RJ 20231-050, Brazil
2
Laboratório de Interações Celulares, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro Prédio de Ciências da Saúde—Cidade Universitária, Ilha do Fundão, A. Carlos Chagas, 373—bloco F, sala 26, Rio de Janeiro, RJ 21941-902, Brasil
3
Istituto di Endocrinologia e Oncologia Sperimentale—CNR c/o Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli “Federico II”, via Pansini 5, 80131 Naples, Italy
4
Divisão de Patologia, Instituto Nacional de Câncer—INCA, Rua Cordeiro da Graça, 156—Santo Cristo, Rio de Janeiro, RJ 20220-040, Brazil
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Laboratório de Toxicologia e Biologia Molecular, Departamento de Bioquímica, Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Av. 28 de setembro, 87—fundos—4º andar, Rio de Janeiro, RJ 20551-030, Brazil
6
Seção de Ginecologia Oncológica, Hospital de Câncer II, Instituto Nacional de Câncer—INCA, Rua Equador, 835. Santo Cristo, Rio de Janeiro, RJ 20220-410, Brazil
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Genes 2019, 10(5), 372; https://doi.org/10.3390/genes10050372
Received: 23 April 2019 / Revised: 6 May 2019 / Accepted: 6 May 2019 / Published: 15 May 2019
(This article belongs to the Section Molecular Genetics and Genomics)
Endometrioid endometrial carcinomas (EEC) are the most common malignant gynecologic tumors. Despite the increase in EEC molecular knowledge, the identification of new biomarkers involved in disease’s development and/or progression would represent an improvement in its course. High-mobility group A protein (HMGA) family members are frequently overexpressed in a wide range of malignancies, correlating with a poor prognosis. Thus, the aim of this study was to analyze HMGA1 and HMGA2 expression pattern and their potential role as EEC biomarkers. HMGA1 and HMGA2 expression was initially evaluated in a series of 46 EEC tumors (stages IA to IV), and the findings were then validated in The Cancer Genome Atlas (TCGA) EEC cohort, comprising 381 EEC tumors (stages IA to IV). Our results reveal that HMGA1 and HMGA2 mRNA and protein are overexpressed in ECC, but only HMGA1 expression is associated with increased histological grade and tumor size. Moreover, HMGA1 but not HMGA2 overexpression was identified as a negative prognostic factor to EEC patients. Finally, a positive correlation between expression of HMGA1 pseudogenes—HMGA1-P6 and HMGA1-P7—and HMGA1 itself was detected, suggesting HMGA1 pseudogenes may play a role in HMGA1 expression regulation in EEC. Thus, these results indicate that HMGA1 overexpression possesses a potential role as a prognostic biomarker for EEC. View Full-Text
Keywords: endometrial carcinomas; cancer progression; molecular biomarkers endometrial carcinomas; cancer progression; molecular biomarkers
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Palumbo Júnior, A.; de Sousa, V.P.L.; Esposito, F.; De Martino, M.; Forzati, F.; Moreira, F.C.B.; Simão, T.A.; Nasciutti, L.E.; Fusco, A.; Ribeiro Pinto, L.F.; Bessa Pereira Chaves, C.; Meireles Da Costa, N. Overexpression of HMGA1 Figures as a Potential Prognostic Factor in Endometrioid Endometrial Carcinoma (EEC). Genes 2019, 10, 372.

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