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Polymers 2017, 9(8), 364; https://doi.org/10.3390/polym9080364

Hydrogel Based Sensors for Biomedical Applications: An Updated Review

1
Medical Device Research Institute, College of Science and Engineering, Flinders University, Adelaide 5042, SA, Australia
2
Institute for Nano Scale Science & Technology, College of Science and Engineering, Flinders University, Adelaide 5042, SA, Australia
*
Authors to whom correspondence should be addressed.
Received: 20 July 2017 / Revised: 10 August 2017 / Accepted: 12 August 2017 / Published: 16 August 2017
(This article belongs to the Special Issue Hydrogels in Tissue Engineering and Regenerative Medicine)
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Abstract

Biosensors that detect and convert biological reactions to a measurable signal have gained much attention in recent years. Between 1950 and 2017, more than 150,000 papers have been published addressing the applications of biosensors in different industries, but to the best of our knowledge and through careful screening, critical reviews that describe hydrogel based biosensors for biomedical applications are rare. This review discusses the biomedical application of hydrogel based biosensors, based on a search performed through Web of Science Core, PubMed (NLM), and Science Direct online databases for the years 2000–2017. In this review, we consider bioreceptors to be immobilized on hydrogel based biosensors, their advantages and disadvantages, and immobilization techniques. We identify the hydrogels that are most favored for this type of biosensor, as well as the predominant transduction strategies. We explain biomedical applications of hydrogel based biosensors including cell metabolite and pathogen detection, tissue engineering, wound healing, and cancer monitoring, and strategies for small biomolecules such as glucose, lactate, urea, and cholesterol detection are identified. View Full-Text
Keywords: hydrogel based biosensor; hydrogel; bioreceptors; immobilization; biomedical application; transduction strategies hydrogel based biosensor; hydrogel; bioreceptors; immobilization; biomedical application; transduction strategies
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Tavakoli, J.; Tang, Y. Hydrogel Based Sensors for Biomedical Applications: An Updated Review. Polymers 2017, 9, 364.

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