Next Article in Journal
Metal and Ligand Effects on the Construction of Divalent Coordination Polymers Based on bis-Pyridyl-bis-amide and Polycarboxylate Ligands
Next Article in Special Issue
Quartz Microcrystal-Hybridized Organosilicone Encapsulant with Enhanced Optical and Thermal Performances
Previous Article in Journal
Preparation, Characterization and Application of Polysaccharide-Based Metallic Nanoparticles: A Review
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessArticle
Polymers 2017, 9(12), 690;

Plateau-Shaped Flexible Polymer Microelectrode Array for Neural Recording

Medical Device Research Center Medical & Health Device Division, Korea Testing Laboratory, Seoul 52852, Korea
Dental Research Institute, Seoul National University School of Dentistry, Seoul 03080, Korea
Author to whom correspondence should be addressed.
Received: 6 November 2017 / Revised: 4 December 2017 / Accepted: 5 December 2017 / Published: 8 December 2017
(This article belongs to the Special Issue Siloxane-Based Polymers)
Full-Text   |   PDF [5282 KB, uploaded 9 December 2017]   |  


Conventional polymer multielectrode arrays (MEAs) have limitations resulting from a high Young’s modulus, including low conformability and gaps between the electrodes and neurons. These gaps are not a problem in soft tissues such as the brain, due to the repopulation phenomenon. However, gaps can result in signal degradation when recording from a fiber bundle, such as the spinal cord. Methods: We propose a method for fabricating flexible polydimethylsiloxane (PDMS)-based MEAs featuring plateau-shaped microelectrodes. The proposed fabrication technique enables the electrodes on the surface of MEAs to make a tight connection to the neurons, because the wire of the MEA is fabricated to be plateau-shaped, as the Young’s modulus of PDMS is similar to soft tissues and PDMS follows the curvature of the neural tissue due to its high conformability compared to the other polymers. Injury caused by the movement of the MEAs can therefore be minimized. Each electrode has a diameter of 130 μm and the 8-channel array has a center-to-center electrode spacing of 300 μm. The signal-to-noise ratio of the plateau-shaped electrodes was larger than that of recessed electrodes because there was no space between the electrode and neural cell. Reliable neural recordings were possible by adjusting the position of the electrode during the experiment without trapping air under the electrodes. Simultaneous multi-channel neural recordings were successfully achieved from the spinal cord of rodents. We describe the fabrication technique, electrode 3D profile, electrode impedance, and MEA performance in in vivo experiments in rodents. View Full-Text
Keywords: fabrication; multielectrode array (MEA); PDMS; PDMS etching; plateau-shaped electrode; recessed electrode; spinal cord signal recording; underexposure fabrication; multielectrode array (MEA); PDMS; PDMS etching; plateau-shaped electrode; recessed electrode; spinal cord signal recording; underexposure

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Kim, J.-M.; Im, C.; Lee, W.R. Plateau-Shaped Flexible Polymer Microelectrode Array for Neural Recording. Polymers 2017, 9, 690.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top