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Communication

Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2

1
Biomaterials and Bioengineering Laboratory, Centro de Investigación Traslacional San Alberto Magno, Universidad Católica de Valencia San Vicente Mártir, c/Guillem de Castro 94, 46001 Valencia, Spain
2
Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto 606-8507, Japan
*
Authors to whom correspondence should be addressed.
Academic Editors: Tzu-Yu Peng and Dan-Jae Lin
Polymers 2022, 14(7), 1483; https://doi.org/10.3390/polym14071483
Received: 26 February 2022 / Revised: 30 March 2022 / Accepted: 4 April 2022 / Published: 6 April 2022
(This article belongs to the Special Issue Physical and Biological Properties of Polymeric Biomaterials)
The current pandemic is urgently demanding the development of alternative materials capable of inactivating the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the coronavirus 2019 (COVID-19) disease. Calcium alginate is a crosslinked hydrophilic biopolymer with an immense range of biomedical applications due to its excellent chemical, physical, and biological properties. In this study, the cytotoxicity and antiviral activity of calcium alginate in the form of films were studied. The results showed that these films, prepared by solvent casting and subsequent crosslinking with calcium cations, are biocompatible in human keratinocytes and are capable of inactivating enveloped viruses such as bacteriophage phi 6 with a 1.43-log reduction (94.92% viral inactivation) and SARS-CoV-2 Delta variant with a 1.64-log reduction (96.94% viral inactivation) in virus titers. The antiviral activity of these calcium alginate films can be attributed to its compacted negative charges that may bind to viral envelopes inactivating membrane receptors. View Full-Text
Keywords: calcium alginate; SARS-CoV-2; bacteriophage; phi 6; biomaterials; films; hydrogels calcium alginate; SARS-CoV-2; bacteriophage; phi 6; biomaterials; films; hydrogels
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MDPI and ACS Style

Cano-Vicent, A.; Hashimoto, R.; Takayama, K.; Serrano-Aroca, Á. Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2. Polymers 2022, 14, 1483. https://doi.org/10.3390/polym14071483

AMA Style

Cano-Vicent A, Hashimoto R, Takayama K, Serrano-Aroca Á. Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2. Polymers. 2022; 14(7):1483. https://doi.org/10.3390/polym14071483

Chicago/Turabian Style

Cano-Vicent, Alba, Rina Hashimoto, Kazuo Takayama, and Ángel Serrano-Aroca. 2022. "Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2" Polymers 14, no. 7: 1483. https://doi.org/10.3390/polym14071483

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