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Spontaneous Gelation of Adhesive Catechol Modified Hyaluronic Acid and Chitosan

Macromolecular Chemistry Group (LABQUIMAC), Department of Physical Chemistry, Faculty of Science and Technology, University of the Basque Country, UPV/EHU, Barrio Sarriena, s/n, 48940 Leioa, Spain
BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain
i+Med S. Coop. Parque Tecnológico de Álava, Albert Einstein 15, nave 15, 01510 Vitoria-Gasteiz, Spain
Author to whom correspondence should be addressed.
Academic Editor: Luminita Marin
Polymers 2022, 14(6), 1209;
Received: 28 January 2022 / Revised: 10 March 2022 / Accepted: 14 March 2022 / Published: 17 March 2022
Spontaneously formed hydrogels are attracting increasing interest as injectable or wound dressing materials because they do not require additional reactions or toxic crosslinking reagents. Highly valuable properties such as low viscosity before external application, adequate filmogenic capacity, rapid gelation and tissue adhesion are required in order to use them for those therapeutic applications. In addition, biocompatibility and biodegradability are also mandatory. Accordingly, biopolymers, such as hyaluronic acid (HA) and chitosan (CHI), that have shown great potential for wound healing applications are excellent candidates due to their unique physiochemical and biological properties, such as moisturizing and antimicrobial ability, respectively. In this study, both biopolymers were modified by covalent anchoring of catechol groups, and the obtained hydrogels were characterized by studying, in particular, their tissue adhesiveness and film forming capacity for potential skin wound healing applications. Tissue adhesiveness was related to o-quinone formation over time and monitored by visible spectroscopy. Consequently, an opposite effect was observed for both polysaccharides. As gelation advances for HA-CA, it becomes more adhesive, while competitive reactions of quinone in CHI-CA slow down tissue adhesiveness and induce a detriment of the filmogenic properties. View Full-Text
Keywords: hyaluronic acid; chitosan; catechol; tissue adhesive hyaluronic acid; chitosan; catechol; tissue adhesive
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MDPI and ACS Style

Conejo-Cuevas, G.; Ruiz-Rubio, L.; Sáez-Martínez, V.; Pérez-González, R.; Gartziandia, O.; Huguet-Casquero, A.; Pérez-Álvarez, L. Spontaneous Gelation of Adhesive Catechol Modified Hyaluronic Acid and Chitosan. Polymers 2022, 14, 1209.

AMA Style

Conejo-Cuevas G, Ruiz-Rubio L, Sáez-Martínez V, Pérez-González R, Gartziandia O, Huguet-Casquero A, Pérez-Álvarez L. Spontaneous Gelation of Adhesive Catechol Modified Hyaluronic Acid and Chitosan. Polymers. 2022; 14(6):1209.

Chicago/Turabian Style

Conejo-Cuevas, Guillermo, Leire Ruiz-Rubio, Virginia Sáez-Martínez, Raul Pérez-González, Oihane Gartziandia, Amaia Huguet-Casquero, and Leyre Pérez-Álvarez. 2022. "Spontaneous Gelation of Adhesive Catechol Modified Hyaluronic Acid and Chitosan" Polymers 14, no. 6: 1209.

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