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Article

Wide-Ranging Multitool Study of Structure and Porosity of PLGA Scaffolds for Tissue Engineering

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Institute of Photon Technologies of Federal Scientific Research Centre “Crystallography and Photonics” of Russian Academy of Sciences, Pionerskaya 2, Troitsk, 108840 Moscow, Russia
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Diamond Light Source, Harwell Oxford Campus, Didcot OX11 0DE, UK
*
Authors to whom correspondence should be addressed.
Academic Editor: Andrea Maio
Polymers 2021, 13(7), 1021; https://doi.org/10.3390/polym13071021
Received: 25 February 2021 / Revised: 19 March 2021 / Accepted: 23 March 2021 / Published: 25 March 2021
(This article belongs to the Section Polymer Analysis and Characterization)
In this study, the nanoscale transformation of the polylactic-co-glycolic acid (PLGA) internal structure, before and after its supercritical carbon dioxide (sc-CO2) swelling and plasticization, followed by foaming after a CO2 pressure drop, was studied by small-angle X-ray scattering (SAXS) for the first time. A comparative analysis of the internal structure data and porosity measurements for PLGA scaffolds, produced by sc-CO2 processing, on a scale ranging from 0.02 to 1000 μm, was performed by SAXS, helium pycnometry (HP), mercury intrusion porosimetry (MIP) and both “lab-source” and synchrotron X-ray microtomography (micro-CT). This approach opens up possibilities for the wide-scale evaluation, computer modeling, and prediction of the physical and mechanical properties of PLGA scaffolds, as well as their biodegradation behavior in the body. Hence, this study targets optimizing the process parameters of PLGA scaffold fabrication for specific biomedical applications. View Full-Text
Keywords: PLGA scaffolds; supercritical fluid processing; internal structure; porosity; small-angle X-ray scattering; helium pycnometry; mercury intrusion porosimetry; X-ray microtomography PLGA scaffolds; supercritical fluid processing; internal structure; porosity; small-angle X-ray scattering; helium pycnometry; mercury intrusion porosimetry; X-ray microtomography
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MDPI and ACS Style

Buzmakov, A.V.; Dunaev, A.G.; Krivonosov, Y.S.; Zolotov, D.A.; Dyachkova, I.G.; Krotova, L.I.; Volkov, V.V.; Bodey, A.J.; Asadchikov, V.E.; Popov, V.K. Wide-Ranging Multitool Study of Structure and Porosity of PLGA Scaffolds for Tissue Engineering. Polymers 2021, 13, 1021. https://doi.org/10.3390/polym13071021

AMA Style

Buzmakov AV, Dunaev AG, Krivonosov YS, Zolotov DA, Dyachkova IG, Krotova LI, Volkov VV, Bodey AJ, Asadchikov VE, Popov VK. Wide-Ranging Multitool Study of Structure and Porosity of PLGA Scaffolds for Tissue Engineering. Polymers. 2021; 13(7):1021. https://doi.org/10.3390/polym13071021

Chicago/Turabian Style

Buzmakov, Alexey V., Andrey G. Dunaev, Yuriy S. Krivonosov, Denis A. Zolotov, Irina G. Dyachkova, Larisa I. Krotova, Vladimir V. Volkov, Andrew J. Bodey, Victor E. Asadchikov, and Vladimir K. Popov 2021. "Wide-Ranging Multitool Study of Structure and Porosity of PLGA Scaffolds for Tissue Engineering" Polymers 13, no. 7: 1021. https://doi.org/10.3390/polym13071021

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