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Article

Bacterial Cellulose-Based Nanocomposites Containing Ceria and Their Use in the Process of Stem Cell Proliferation

1
Institute of Macromolecular Compounds, Russian Academy of Sciences, 199004 Saint Petersburg, Russia
2
H. Turner National Medical Research Center for Children’s Orthopedics and Trauma Surgery, Pushkin, 196603 Saint Petersburg, Russia
3
Institute of Chemistry, Saint Petersburg State University, 198504 Saint Petersburg, Russia
4
Institute of Silicate Chemistry, Russian Academy of Sciences, 199034 Saint Petersburg, Russia
5
Institute of Theoretical and Experimental Biophysics, 142290 Pushchino, Russia
6
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russia
7
Research Institute for Physical and Chemical Problems, Belarusian State University, 220030 Minsk, Belarus
*
Author to whom correspondence should be addressed.
Academic Editor: Yung-Sheng Yen
Polymers 2021, 13(12), 1999; https://doi.org/10.3390/polym13121999
Received: 20 May 2021 / Revised: 15 June 2021 / Accepted: 16 June 2021 / Published: 18 June 2021
(This article belongs to the Special Issue Advances in Polymer Composites)
A technique for the fabrication of bacterial cellulose-based films with CeO2 nanofiller has been developed. The structural and morphological characteristics of the materials have been studied, their thermal and mechanical properties in dry and swollen states having been determined. The preparation methodology makes it possible to obtain composites with a uniform distribution of nanoparticles. The catalytic effect of ceria, regarding the thermal oxidative destruction of cellulose, has been confirmed by TGA and DTA methods. An increase in CeO2 content led to an increase in the elastic modulus (a 1.27-fold increase caused by the introduction of 5 wt.% of the nanofiller into the polymer) and strength of the films. This effect is explained by the formation of additional links between polymer macro-chains via the nanoparticles’ surface. The materials fabricated were characterized by a limited ability to swell in water. Swelling caused a 20- to 30-fold reduction in the stiffness of the material, the mechanical properties of the films in a swollen state remaining germane to their practical use. The application of the composite films in cell engineering as substrates for the stem cells’ proliferation has been studied. The increase in CeO2 content in the films enhanced the proliferative activity of embryonic mouse stem cells. The cells cultured on the scaffold containing 5 wt.% of ceria demonstrated increased cell survival and migration activity. An analysis of gene expression confirmed improved cultivation conditions on CeO2-containing scaffolds. View Full-Text
Keywords: nanocomposites; bacterial cellulose; ceria nanoparticles; thermal properties; swelling; mechanical behavior; biomedical applications; stem cells proliferation; gene expression nanocomposites; bacterial cellulose; ceria nanoparticles; thermal properties; swelling; mechanical behavior; biomedical applications; stem cells proliferation; gene expression
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MDPI and ACS Style

Gofman, I.V.; Nikolaeva, A.L.; Khripunov, A.K.; Ivan’kova, E.M.; Shabunin, A.S.; Yakimansky, A.V.; Romanov, D.P.; Popov, A.L.; Ermakov, A.M.; Solomevich, S.O.; Bychkovsky, P.M.; Baranchikov, A.E.; Ivanov, V.K. Bacterial Cellulose-Based Nanocomposites Containing Ceria and Their Use in the Process of Stem Cell Proliferation. Polymers 2021, 13, 1999. https://doi.org/10.3390/polym13121999

AMA Style

Gofman IV, Nikolaeva AL, Khripunov AK, Ivan’kova EM, Shabunin AS, Yakimansky AV, Romanov DP, Popov AL, Ermakov AM, Solomevich SO, Bychkovsky PM, Baranchikov AE, Ivanov VK. Bacterial Cellulose-Based Nanocomposites Containing Ceria and Their Use in the Process of Stem Cell Proliferation. Polymers. 2021; 13(12):1999. https://doi.org/10.3390/polym13121999

Chicago/Turabian Style

Gofman, Iosif V., Alexandra L. Nikolaeva, Albert K. Khripunov, Elena M. Ivan’kova, Anton S. Shabunin, Alexander V. Yakimansky, Dmitriy P. Romanov, Anton L. Popov, Artem M. Ermakov, Sergey O. Solomevich, Pavel M. Bychkovsky, Alexander E. Baranchikov, and Vladimir K. Ivanov 2021. "Bacterial Cellulose-Based Nanocomposites Containing Ceria and Their Use in the Process of Stem Cell Proliferation" Polymers 13, no. 12: 1999. https://doi.org/10.3390/polym13121999

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