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Communication

Micromechanical Punching: A Versatile Method for Non-Spherical Microparticle Fabrication

1
DNRF and Villum Fonden Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, IDUN, DTU Health Technology, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
2
National Centre of Nano Fabrication and Characterization, DTU Nanolab, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
3
Department of Health Technology, DTU Health Tech, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
*
Author to whom correspondence should be addressed.
Polymers 2021, 13(1), 83; https://doi.org/10.3390/polym13010083
Received: 27 November 2020 / Revised: 21 December 2020 / Accepted: 23 December 2020 / Published: 28 December 2020
(This article belongs to the Special Issue Polymer Micro/Nanofabrication and Manufacturing)
Microparticles are ubiquitous in applications ranging from electronics and drug delivery to cosmetics and food. Conventionally, non-spherical microparticles in various materials with specific shapes, sizes, and physicochemical properties have been fabricated using cleanroom-free lithography techniques such as soft lithography and its high-resolution version particle replication in non-wetting template (PRINT). These methods process the particle material in its liquid/semi-liquid state by deformable molds, limiting the materials from which the particles and the molds can be fabricated. In this study, the microparticle material is exploited as a sheet placed on a deformable substrate, punched by a robust mold. Drawing inspiration from the macro-manufacturing technique of punching metallic sheets, Micromechanical Punching (MMP) is a high-throughput technique for fabrication of non-spherical microparticles. MMP allows production of microparticles from prepatterned, porous, and fibrous films, constituting thermoplastics and thermosetting polymers. As an illustration of application of MMP in drug delivery, flat, microdisk-shaped Furosemide embedded poly(lactic-co-glycolic acid) microparticles are fabricated and Furosemide release is observed. Thus, it is shown in the paper that Micromechanical punching has potential to make micro/nanofabrication more accessible to the research and industrial communities active in applications that require engineered particles. View Full-Text
Keywords: non-spherical microparticle; soft lithography; drug delivery; punching non-spherical microparticle; soft lithography; drug delivery; punching
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MDPI and ACS Style

Petersen, R.S.; Boisen, A.; Keller, S.S. Micromechanical Punching: A Versatile Method for Non-Spherical Microparticle Fabrication. Polymers 2021, 13, 83. https://doi.org/10.3390/polym13010083

AMA Style

Petersen RS, Boisen A, Keller SS. Micromechanical Punching: A Versatile Method for Non-Spherical Microparticle Fabrication. Polymers. 2021; 13(1):83. https://doi.org/10.3390/polym13010083

Chicago/Turabian Style

Petersen, Ritika S., Anja Boisen, and Stephan S. Keller 2021. "Micromechanical Punching: A Versatile Method for Non-Spherical Microparticle Fabrication" Polymers 13, no. 1: 83. https://doi.org/10.3390/polym13010083

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