Next Article in Journal
A Semi-Dissolving Microneedle Patch Incorporating TEMPO-Oxidized Bacterial Cellulose Nanofibers for Enhanced Transdermal Delivery
Next Article in Special Issue
Effect of Stereolithography 3D Printing on the Properties of PEGDMA Hydrogels
Previous Article in Journal
Ameliorated Performance of Sulfonated Poly(Arylene Ether Sulfone) Block Copolymers with Increased Hydrophilic Oligomer Ratio in Proton-Exchange Membrane Fuel Cells Operating at 80% Relative Humidity
Previous Article in Special Issue
Natural 3D-Printed Bioinks for Skin Regeneration and Wound Healing: A Systematic Review
Article

Novel On-Demand 3-Dimensional (3-D) Printed Tablets Using Fill Density as an Effective Release-Controlling Tool

Pharmaceutical Engineering and 3D Printing (PharmE3D) Labs, Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78705, USA
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(9), 1872; https://doi.org/10.3390/polym12091872
Received: 22 July 2020 / Revised: 7 August 2020 / Accepted: 18 August 2020 / Published: 20 August 2020
(This article belongs to the Special Issue 3D and 4D Printing of (Bio)Materials)
This research demonstrates the use of fill density as an effective tool for controlling the drug release without changing the formulation composition. The merger of hot-melt extrusion (HME) with fused deposition modeling (FDM)-based 3-dimensional (3-D) printing processes over the last decade has directed pharmaceutical research towards the possibility of printing personalized medication. One key aspect of printing patient-specific dosage forms is controlling the release dynamics based on the patient’s needs. The purpose of this research was to understand the impact of fill density and interrelate it with the release of a poorly water-soluble, weakly acidic, active pharmaceutical ingredient (API) from a hydroxypropyl methylcellulose acetate succinate (HPMC-AS) matrix, both mathematically and experimentally. Amorphous solid dispersions (ASDs) of ibuprofen with three grades of AquaSolveTM HPMC-AS (HG, MG, and LG) were developed using an HME process and evaluated using solid-state characterization techniques. Differential scanning calorimetry (DSC), powder X-ray diffraction (pXRD), and polarized light microscopy (PLM) confirmed the amorphous state of the drug in both polymeric filaments and 3D printed tablets. The suitability of the manufactured filaments for FDM processes was investigated using texture analysis (TA) which showed robust mechanical properties of the developed filament compositions. Using FDM, tablets with different fill densities (20–80%) and identical dimensions were printed for each polymer. In vitro pH shift dissolution studies revealed that the fill density has a significant impact (F(11, 24) = 15,271.147, p < 0.0001) and a strong negative correlation (r > −0.99; p < 0.0001) with the release performance, where 20% infill demonstrated the fastest and most complete release, whereas 80% infill depicted a more controlled release. The results obtained from this research can be used to develop a robust formulation strategy to control the drug release from 3D printed dosage forms as a function of fill density. View Full-Text
Keywords: fused deposition modeling; additive manufacturing; HPMC-AS; controlled release; personalized medication; hot-melt extrusion; amorphous solid dispersions fused deposition modeling; additive manufacturing; HPMC-AS; controlled release; personalized medication; hot-melt extrusion; amorphous solid dispersions
Show Figures

Graphical abstract

MDPI and ACS Style

Thakkar, R.; Pillai, A.R.; Zhang, J.; Zhang, Y.; Kulkarni, V.; Maniruzzaman, M. Novel On-Demand 3-Dimensional (3-D) Printed Tablets Using Fill Density as an Effective Release-Controlling Tool. Polymers 2020, 12, 1872. https://doi.org/10.3390/polym12091872

AMA Style

Thakkar R, Pillai AR, Zhang J, Zhang Y, Kulkarni V, Maniruzzaman M. Novel On-Demand 3-Dimensional (3-D) Printed Tablets Using Fill Density as an Effective Release-Controlling Tool. Polymers. 2020; 12(9):1872. https://doi.org/10.3390/polym12091872

Chicago/Turabian Style

Thakkar, Rishi, Amit R. Pillai, Jiaxiang Zhang, Yu Zhang, Vineet Kulkarni, and Mohammed Maniruzzaman. 2020. "Novel On-Demand 3-Dimensional (3-D) Printed Tablets Using Fill Density as an Effective Release-Controlling Tool" Polymers 12, no. 9: 1872. https://doi.org/10.3390/polym12091872

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop