Next Article in Journal
Mechanical Strength, Thermal Conductivity and Electrical Breakdown of Kenaf Core Fiber/Lignin/Polypropylene Biocomposite
Next Article in Special Issue
AC Electrokinetics of Salt-Free Multilayered Polymer-Grafted Particles
Previous Article in Journal
Association between Nonionic Amphiphilic Polymer and Ionic Surfactant in Aqueous Solutions: Effect of Polymer Hydrophobicity and Micellization
Previous Article in Special Issue
Creation of a PDMS Polymer Brush on SiO2-Based Nanoparticles by Surface-Initiated Ring-Opening Polymerization
Article

Nanoformulation Design Including MamC-Mediated Biomimetic Nanoparticles Allows the Simultaneous Application of Targeted Drug Delivery and Magnetic Hyperthermia

1
Department of Microbiology, Faculty of Sciences, University of Granada, 18071 Granada, Spain
2
Department of Biochemistry and Molecular Biology I, University of Granada, 18071 Granada, Spain
3
Dipartimento di Scienze della Salute, Università del Piemonte Orientale “A. Avogadro”, Via Solaroli 17, 28100 Novara, Italy
4
Centro di Biotecnologie per la Ricerca Medica Applicata (BRMA), Via Solaroli 17, 28100 Novara, Italy
5
Consorzio Interuniversitario per Biotecnologie (CIB), Località Padriciano 99, 34149 Area di Ricerca, Italy
6
Consorzio Interuniversitario Nazionale per la Scienza e Tecnologia dei Materiali (INSTM), Via G. Giusti 9, 50121 Firenze, Italy
7
Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici (CIRCMSB), Piazza Umberto I, 1, 70121 Bari, Italy
8
Centro Interdipartimentale di Medicina Rigenerativa (CIMeR), Via Montpellier, 1, 00133 Roma, Italy
9
Department of Applied Physics, Faculty of Sciences, University of Granada, 18071 Granada, Spain
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Polymers 2020, 12(8), 1832; https://doi.org/10.3390/polym12081832
Received: 30 July 2020 / Accepted: 13 August 2020 / Published: 15 August 2020
(This article belongs to the Special Issue Nanoparticle Functionalization by Polymers: Methods and Applications)
The design of novel nanomaterials that can be used as multifunctional platforms allowing the combination of therapies is gaining increased interest. Moreover, if this nanomaterial is intended for a targeted drug delivery, the use of several guidance methods to increase guidance efficiency is also crucial. Magnetic nanoparticles (MNPs) allow this combination of therapies and guidance strategies. In fact, MNPs can be used simultaneously as drug nanocarriers and magnetic hyperthermia agents and, moreover, they can be guided toward the target by an external magnetic field and by their functionalization with a specific probe. However, it is difficult to find a system based on MNPs that exhibits optimal conditions as a drug nanocarrier and as a magnetic hyperthermia agent. In this work, a novel nanoformulation is proposed to be used as a multifunctional platform that also allows dual complementary guidance. This nanoformulation is based on mixtures of inorganic magnetic nanoparticles (M) that have been shown to be optimal hyperthermia agents, and biomimetic magnetic nanoparticles (BM), that have been shown to be highly efficient drug nanocarriers. The presence of the magnetosome protein MamC at the surface of BM confers novel surface properties that allow for the efficient and stable functionalization of these nanoparticles without the need of further coating, with the release of the relevant molecule being pH-dependent, improved by magnetic hyperthermia. The BM are functionalized with Doxorubicin (DOXO) as a model drug and with an antibody that allows for dual guidance based on a magnetic field and on an antibody. The present study represents a proof of concept to optimize the nanoformulation composition in order to provide the best performance in terms of the magnetic hyperthermia agent and drug nanocarrier. View Full-Text
Keywords: magnetic hyperthermia; magnetic nanoparticles; biomimetic magnetic nanoparticles; MamC; tumor combined dual targeting; doxorubicin magnetic hyperthermia; magnetic nanoparticles; biomimetic magnetic nanoparticles; MamC; tumor combined dual targeting; doxorubicin
Show Figures

Graphical abstract

MDPI and ACS Style

Jabalera, Y.; Oltolina, F.; Peigneux, A.; Sola-Leyva, A.; Carrasco-Jiménez, M.P.; Prat, M.; Jimenez-Lopez, C.; Iglesias, G.R. Nanoformulation Design Including MamC-Mediated Biomimetic Nanoparticles Allows the Simultaneous Application of Targeted Drug Delivery and Magnetic Hyperthermia. Polymers 2020, 12, 1832. https://doi.org/10.3390/polym12081832

AMA Style

Jabalera Y, Oltolina F, Peigneux A, Sola-Leyva A, Carrasco-Jiménez MP, Prat M, Jimenez-Lopez C, Iglesias GR. Nanoformulation Design Including MamC-Mediated Biomimetic Nanoparticles Allows the Simultaneous Application of Targeted Drug Delivery and Magnetic Hyperthermia. Polymers. 2020; 12(8):1832. https://doi.org/10.3390/polym12081832

Chicago/Turabian Style

Jabalera, Ylenia, Francesca Oltolina, Ana Peigneux, Alberto Sola-Leyva, Maria P. Carrasco-Jiménez, Maria Prat, Concepcion Jimenez-Lopez, and Guillermo R. Iglesias 2020. "Nanoformulation Design Including MamC-Mediated Biomimetic Nanoparticles Allows the Simultaneous Application of Targeted Drug Delivery and Magnetic Hyperthermia" Polymers 12, no. 8: 1832. https://doi.org/10.3390/polym12081832

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop