Next Article in Journal
Medical Application of Polymer-Based Composites
Previous Article in Journal
Double-Crosslinked Polyurethane Acrylate for Highly Conductive and Stable Polymer Electrolyte
Previous Article in Special Issue
Energy-Saving Electrospinning with a Concentric Teflon-Core Rod Spinneret to Create Medicated Nanofibers
Open AccessArticle

Novel Electrospun Pullulan Fibers Incorporating Hydroxypropyl-β-Cyclodextrin: Morphology and Relation with Rheological Properties

1
Department of Food Science and Technology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
2
Department of Chemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
3
Macromolecules Innovation Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(11), 2558; https://doi.org/10.3390/polym12112558
Received: 22 September 2020 / Revised: 26 October 2020 / Accepted: 28 October 2020 / Published: 31 October 2020
(This article belongs to the Special Issue Functional Electrospun Nanofibers)
Fibers produced by electrospinning from biocompatible, biodegradable and naturally occurring polymers have potential advantages in drug delivery and biomedical applications because of their unique functionalities. Here, electrospun submicron fibers were produced from mixtures containing an exopolysaccharide (pullulan) and a small molecule with hosting abilities, hydroxypropyl-β-cyclodextrin (HP-β-CD), thus serving as multi-functional blend. The procedure used water as sole solvent and excluded synthetic polymers. Rheological characterization was performed to evaluate the impact of HP-β-CD on pullulan entanglement concentration (CE); the relationship with electrospinnability and fiber morphology was investigated. Neat pullulan solutions required three times CE (~20% w/v pullulan) for effective electrospinning and formation of bead-free nanofibers. HP-β-CD (30% w/v) facilitated electrospinning, leading to the production of continuous, beadless fibers (average diameters: 853-1019 nm) at lower polymer concentrations than those required in neat pullulan systems, without significantly shifting the polymer CE. Rheological, Differential Scanning Calorimetry (DSC) and Dynamic Light Scattering (DLS) measurements suggested that electrospinnability improvement was due to HP-β-CD assisting in pullulan entanglement, probably acting as a crosslinker. Yet, the type of association was not clearly identified. This study shows that blending pullulan with HP-β-CD offers a platform to exploit the inherent properties and advantages of both components in encapsulation applications. View Full-Text
Keywords: pullulan; hydroxypropyl-β-cyclodextrin; electrospinning; rheology; entanglement concentration pullulan; hydroxypropyl-β-cyclodextrin; electrospinning; rheology; entanglement concentration
Show Figures

Figure 1

MDPI and ACS Style

Poudel, D.; Swilley-Sanchez, S.; O’keefe, S.; Matson, J.; Long, T.; Fernández-Fraguas, C. Novel Electrospun Pullulan Fibers Incorporating Hydroxypropyl-β-Cyclodextrin: Morphology and Relation with Rheological Properties. Polymers 2020, 12, 2558. https://doi.org/10.3390/polym12112558

AMA Style

Poudel D, Swilley-Sanchez S, O’keefe S, Matson J, Long T, Fernández-Fraguas C. Novel Electrospun Pullulan Fibers Incorporating Hydroxypropyl-β-Cyclodextrin: Morphology and Relation with Rheological Properties. Polymers. 2020; 12(11):2558. https://doi.org/10.3390/polym12112558

Chicago/Turabian Style

Poudel, Deepak; Swilley-Sanchez, Sarah; O’keefe, Sean; Matson, John; Long, Timothy; Fernández-Fraguas, Cristina. 2020. "Novel Electrospun Pullulan Fibers Incorporating Hydroxypropyl-β-Cyclodextrin: Morphology and Relation with Rheological Properties" Polymers 12, no. 11: 2558. https://doi.org/10.3390/polym12112558

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop