Next Article in Journal
Sequential Recovery of Heavy and Noble Metals by Mussel-Inspired Polydopamine-Polyethyleneimine Conjugated Polyurethane Composite Bearing Dithiocarbamate Moieties
Previous Article in Journal
Fabrication, Crystalline Behavior, Mechanical Property and In-Vivo Degradation of Poly(l–lactide) (PLLA)–Magnesium Oxide Whiskers (MgO) Nano Composites Prepared by In-Situ Polymerization
Previous Article in Special Issue
Influence of Starch Composition and Molecular Weight on Physicochemical Properties of Biodegradable Films
Article Menu

Export Article

Open AccessArticle

Opuntia Ficus-Indica L. Miller (Palma Forrageira) as an Alternative Source of Cellulose for Production of Pharmaceutical Dosage Forms and Biomaterials: Extraction and Characterization

1
Graduate Program of Pharmaceutical Sciences, State University of Paraíba, Campina Grande 58429-500—PB, Brazil
2
Laboratory of Development and Characterization of Pharmaceutical Products, Department of Pharmacy, State University of Paraíba, Campina Grande 58429-500—PB, Brazil
3
Graduate Program of Biotechnology, Laureate International Universities—Universidade Potiguar, Natal 59056-000—RN, Brazil
*
Authors to whom correspondence should be addressed.
Polymers 2019, 11(7), 1124; https://doi.org/10.3390/polym11071124
Received: 19 April 2019 / Revised: 19 June 2019 / Accepted: 28 June 2019 / Published: 2 July 2019
(This article belongs to the Special Issue Synthesis and Characterization of Bio-Based Polymers)
  |  
PDF [2289 KB, uploaded 2 July 2019]
  |     |  

Abstract

Cellulose is among the top 5 excipients used in the pharmaceutical industry. It has been considered one of the main diluents used in conventional and modern dosage forms. Therefore, different raw materials of plant origin have been evaluated as potential alternative sources of cellulose. In this context, Opuntia ficus-indica L. Miller (palma forrageira), a plant of the cactus family that has physiological mechanisms that provide greater productivity with reduced water requirements, is an interesting and unexplored alternative for extracting cellulose. By using this source, we aim to decrease the extraction stages and increase the yields, which might result in a decreased cost for the industry and consequently for the consumer. The aim of this work was to investigate the use of Opuntia ficus-indica L. Miller as a new source for cellulose extraction, therefore providing an efficient, straight forward and low-cost method of cellulose II production. The extraction method is based on the oxidation of the lignins. The obtained cellulose was identified and characterized by spectroscopic methods (FTIR and NMR), X-ray diffraction, thermal analysis (TGA-DTG and DSC) and scanning electron microscopy. The results confirmed the identity of cellulose and its fibrous nature, which are promising characteristics for its use in the industry and a reasonable substrate for chemical modifications for the synthesis of cellulose II derivatives with different physicochemical properties that might be used in the production of drug delivery systems and biomaterials. View Full-Text
Keywords: celullose; Opuntia ficus-indica L. Miller (palma forrageira); pharmaceutical excipients celullose; Opuntia ficus-indica L. Miller (palma forrageira); pharmaceutical excipients
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

de Assis, A.C.L.; Alves, L.P.; Malheiro, J.P.T.; Barros, A.R.A.; Pinheiro-Santos, E.E.; de Azevedo, E.P.; Silva Alves, H.; Oshiro-Junior, J.A.; Damasceno, B.P.G.L. Opuntia Ficus-Indica L. Miller (Palma Forrageira) as an Alternative Source of Cellulose for Production of Pharmaceutical Dosage Forms and Biomaterials: Extraction and Characterization. Polymers 2019, 11, 1124.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Polymers EISSN 2073-4360 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top