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Open AccessArticle

Radiation Degradation of β-Glucan with a Potential for Reduction of Lipids and Glucose in the Blood of Mice

1
Nha Trang Vaccines and Biological Products Joint-Stock Company, Khanh Hoa, Viet Nam
2
Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ha Noi, Viet Nam
3
Biotechnology Center of Ho Chi Minh City, Ho Chi Minh City, Viet Nam
4
Nguyen Tat Thanh University, Ho Chi Minh City, Viet Nam
5
Institute of Tropical Biology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Viet Nam
6
Hochiminh University of Natural Resource and Environment, Ho Chi Minh City, Viet Nam
*
Author to whom correspondence should be addressed.
Polymers 2019, 11(6), 955; https://doi.org/10.3390/polym11060955
Received: 12 April 2019 / Revised: 27 May 2019 / Accepted: 1 June 2019 / Published: 1 June 2019
Water-soluble and low molecular weight (Mw) β-glucans were successfully prepared by γ-irradiation of water-insoluble yeast β-glucans. The radiation dose used for the degradation of yeast β-glucan was remarkably reduced by increasing the pH of the sample or combining with hydrogen peroxide treatment. Radiation-degraded β-glucans with molecular weights in the range of 11−48 kDa reduced the total cholesterol, triglyceride, low density lipoprotein (LDL) cholesterol, and glucose levels in the blood of administered mice. The decreasing levels of both lipid and glucose indexes in the blood of tested mice strongly depended on the molecular weight of the β-glucan, and the radiation-degraded β-glucan with a molecular weight of about 25 kDa was found to be the most effective for the reduction of blood lipid and glucose levels. Particularly, the oral administration of 25 kDa β-glucan, with a daily dose of about 2 mg per head, reduced the total cholesterol, triglyceride, LDL-cholesterol, and glucose levels in the blood of tested mice to about 47.4%, 48.5%, 45.7%, and 47.2%, respectively. The effects on the reduction of blood lipid and glucose levels were also found to be stable after 20 days of stopping administration. These results indicate that the degraded β-glucan with a molecular weight of about 25 kDa prepared by γ-ray irradiation is a very promising ingredient that can be used in nutraceutical food for therapeutics of diabetic and dyslipidemia. View Full-Text
Keywords: degradation; irradiation; low molecular weight β-glucan; water-soluble β-glucan; diabetic; dyslipidemia degradation; irradiation; low molecular weight β-glucan; water-soluble β-glucan; diabetic; dyslipidemia
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Long, N.T.; Anh, N.T.N.; Giang, B.L.; Son, H.N.; Luan, L.Q. Radiation Degradation of β-Glucan with a Potential for Reduction of Lipids and Glucose in the Blood of Mice. Polymers 2019, 11, 955.

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